Cargando…

Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popova, Semiramis A., Buczacki, Simon J. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Author's Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149862/ https://www.ncbi.nlm.nih.gov/pubmed/30250932 http://dx.doi.org/10.1080/23723556.2018.1494950

Ejemplares similares

Itraconazole targets cell cycle heterogeneity in colorectal cancer
por: Buczacki, Simon J.A., et al.
Publicado: (2018)

A novel preclinical murine model of immune-mediated metastatic dormancy
por: Romero, Irene, et al.
Publicado: (2014)

Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells
por: Liang, Hua, et al.
Publicado: (2013)

Disrupting the endothelin and Wnt relationship to overcome chemoresistance
por: Rosanò, Laura, et al.
Publicado: (2015)

DDR1 inhibition as a new therapeutic strategy for colorectal cancer
por: Sirvent, Audrey, et al.
Publicado: (2018)

Resistance to kinase inhibition through shortened target engagement
por: Rangwala, Aziz M., et al.
Publicado: (2022)

WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC
por: Göndör, Anita
Publicado: (2020)

Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment
por: Michielsen, Adriana J., et al.
Publicado: (2012)

CD44 regulates Wnt signaling at the level of LRP6
por: Orian-Rousseau, Véronique, et al.
Publicado: (2015)

Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation
por: Michielsen, Adriana J., et al.
Publicado: (2012)

Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition
por: McQuade, Jennifer L, et al.
Publicado: (2015)

A novel miRNA-mediated STOP sign in lung cancer: miR-340 inhibits the proliferation of lung cancer cells through p27(KIP1)
por: Fernandez, Serena, et al.
Publicado: (2015)

Improving VEGF-targeted therapies through inhibition of COX-2/PGE(2) signaling
por: Xu, Lihong, et al.
Publicado: (2014)

β-catenin-mediated inhibition of cross-priming: A new mechanism for tumors to evade immunosurveillance
por: Fu, Chunmei, et al.
Publicado: (2013)

Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling
por: Demagny, Hadrien, et al.
Publicado: (2015)

The colorectal cancer immune paradox revisited
por: Angelova, Mihaela, et al.
Publicado: (2015)

Macrophages: Good guys in colorectal cancer
por: Edin, Sofia, et al.
Publicado: (2013)

Hunting for clues: Regulatory T cells and colorectal cancer
por: Gallimore, Awen, et al.
Publicado: (2012)

Personalized peptide vaccination for advanced colorectal cancer
por: Sasada, Tetsuro, et al.
Publicado: (2015)

LPCAT2 controls chemoresistance in colorectal cancer
por: Cotte, Alexia Karen, et al.
Publicado: (2018)

Multiverse of immune microenvironment in metastatic colorectal cancer
por: Van den Eynde, Marc, et al.
Publicado: (2020)

Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
por: Hirt, Christian, et al.
Publicado: (2013)

Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?
por: Martens, Alexander, et al.
Publicado: (2014)

Toll-like receptor genetic variants and colorectal cancer
por: Weber, Alexander NR, et al.
Publicado: (2014)

Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer
por: Iskar, Murat, et al.
Publicado: (2015)

The role of FOXP3 in disease progression in colorectal cancer patients
por: Grimmig, Tanja, et al.
Publicado: (2013)

Stromal CEACAM1 expression regulates colorectal cancer metastasis
por: Arabzadeh, Azadeh, et al.
Publicado: (2012)

GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
por: Chen, Guojiang, et al.
Publicado: (2014)

BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?
por: Herr, Ricarda, et al.
Publicado: (2015)

The consensus immunoscore: toward a new classification of colorectal cancer
por: Lanzi, Anastasia, et al.
Publicado: (2020)

Targeting copper metabolism to defeat KRAS-driven colorectal cancer
por: Aubert, Léo, et al.
Publicado: (2020)

Interleukin 21 impairs tumor immunosurveillance of colitis-associated colorectal cancer
por: Kesselring, Rebecca, et al.
Publicado: (2012)

Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer
por: Thibaudin, Marion, et al.
Publicado: (2023)

Rage mediated DAMP signaling in intestinal tumorigenesis
por: Heijmans, Jarom, et al.
Publicado: (2012)

Rapamycin: A rheostat for CD8(+) T-cell-mediated tumor therapy
por: Srivastava, Rupesh K., et al.
Publicado: (2012)

A mechanism for the response of KRAS(G13D) expressing colorectal cancers to EGFR inhibitors
por: McFall, Thomas, et al.
Publicado: (2020)

Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting
por: Birklé, Stéphane, et al.
Publicado: (2013)

Bad to the bone: B cell acute lymphoblastic leukemia cells mediate bone destruction
por: Rajakumar, Sujeetha A., et al.
Publicado: (2020)

A new “angle” on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition
por: Meyerowitz, Justin G, et al.
Publicado: (2015)

Targeting MYC through WDR5
por: Thomas, Lance R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mjroo1r791ots7jsdjhlfafb7r