Targeting endosomal pH for cancer chemotherapy

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribu...

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Detalles Bibliográficos
Autores principales: Lucien, Fabrice, Lavoie, Roxane R., Dubois, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149877/
https://www.ncbi.nlm.nih.gov/pubmed/30250892
http://dx.doi.org/10.1080/23723556.2018.1435184
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author Lucien, Fabrice
Lavoie, Roxane R.
Dubois, Claire M.
author_facet Lucien, Fabrice
Lavoie, Roxane R.
Dubois, Claire M.
author_sort Lucien, Fabrice
collection PubMed
description Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).
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spelling pubmed-61498772019-03-13 Targeting endosomal pH for cancer chemotherapy Lucien, Fabrice Lavoie, Roxane R. Dubois, Claire M. Mol Cell Oncol Author's Views Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6). Taylor & Francis 2018-03-13 /pmc/articles/PMC6149877/ /pubmed/30250892 http://dx.doi.org/10.1080/23723556.2018.1435184 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Lucien, Fabrice
Lavoie, Roxane R.
Dubois, Claire M.
Targeting endosomal pH for cancer chemotherapy
title Targeting endosomal pH for cancer chemotherapy
title_full Targeting endosomal pH for cancer chemotherapy
title_fullStr Targeting endosomal pH for cancer chemotherapy
title_full_unstemmed Targeting endosomal pH for cancer chemotherapy
title_short Targeting endosomal pH for cancer chemotherapy
title_sort targeting endosomal ph for cancer chemotherapy
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149877/
https://www.ncbi.nlm.nih.gov/pubmed/30250892
http://dx.doi.org/10.1080/23723556.2018.1435184
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AT lavoieroxaner targetingendosomalphforcancerchemotherapy
AT duboisclairem targetingendosomalphforcancerchemotherapy

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