Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model

Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work...

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Detalles Bibliográficos
Autores principales: Sato, Taku, Morita, Mami, Nomura, Miyuki, Tanuma, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149909/
https://www.ncbi.nlm.nih.gov/pubmed/30250920
http://dx.doi.org/10.1080/23723556.2018.1472054
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author Sato, Taku
Morita, Mami
Nomura, Miyuki
Tanuma, Nobuhiro
author_facet Sato, Taku
Morita, Mami
Nomura, Miyuki
Tanuma, Nobuhiro
author_sort Sato, Taku
collection PubMed
description Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work provides new insight into cancer metabolism.
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spelling pubmed-61499092019-08-01 Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model Sato, Taku Morita, Mami Nomura, Miyuki Tanuma, Nobuhiro Mol Cell Oncol Author's Views Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work provides new insight into cancer metabolism. Taylor & Francis 2018-08-01 /pmc/articles/PMC6149909/ /pubmed/30250920 http://dx.doi.org/10.1080/23723556.2018.1472054 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Sato, Taku
Morita, Mami
Nomura, Miyuki
Tanuma, Nobuhiro
Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title_full Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title_fullStr Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title_full_unstemmed Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title_short Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
title_sort revisiting glucose metabolism in cancer: lessons from a pkm knock-in model
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149909/
https://www.ncbi.nlm.nih.gov/pubmed/30250920
http://dx.doi.org/10.1080/23723556.2018.1472054
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AT tanumanobuhiro revisitingglucosemetabolismincancerlessonsfromapkmknockinmodel

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