A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells

Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These resul...

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Detalles Bibliográficos
Autores principales: Drummond, Catherine J., Hatley, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149917/
https://www.ncbi.nlm.nih.gov/pubmed/30250910
http://dx.doi.org/10.1080/23723556.2018.1448246
Descripción
Sumario:Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue.

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