A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells

Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These resul...

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Detalles Bibliográficos
Autores principales: Drummond, Catherine J., Hatley, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149917/
https://www.ncbi.nlm.nih.gov/pubmed/30250910
http://dx.doi.org/10.1080/23723556.2018.1448246
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author Drummond, Catherine J.
Hatley, Mark E.
author_facet Drummond, Catherine J.
Hatley, Mark E.
author_sort Drummond, Catherine J.
collection PubMed
description Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue.
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spelling pubmed-61499172019-05-16 A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells Drummond, Catherine J. Hatley, Mark E. Mol Cell Oncol Author's Views Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue. Taylor & Francis 2018-05-16 /pmc/articles/PMC6149917/ /pubmed/30250910 http://dx.doi.org/10.1080/23723556.2018.1448246 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Drummond, Catherine J.
Hatley, Mark E.
A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title_full A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title_fullStr A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title_full_unstemmed A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title_short A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
title_sort case of mistaken identity: rhabdomyosarcoma development from endothelial progenitor cells
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149917/
https://www.ncbi.nlm.nih.gov/pubmed/30250910
http://dx.doi.org/10.1080/23723556.2018.1448246
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