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Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates

Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been appl...

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Autores principales: Peng, Bai-Jing, Wu, Wen-Ting, Yang, Shyh-Chyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149942/
https://www.ncbi.nlm.nih.gov/pubmed/29186044
http://dx.doi.org/10.3390/molecules22122097
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author Peng, Bai-Jing
Wu, Wen-Ting
Yang, Shyh-Chyun
author_facet Peng, Bai-Jing
Wu, Wen-Ting
Yang, Shyh-Chyun
author_sort Peng, Bai-Jing
collection PubMed
description Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles.
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spelling pubmed-61499422018-11-13 Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates Peng, Bai-Jing Wu, Wen-Ting Yang, Shyh-Chyun Molecules Article Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles. MDPI 2017-11-29 /pmc/articles/PMC6149942/ /pubmed/29186044 http://dx.doi.org/10.3390/molecules22122097 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peng, Bai-Jing
Wu, Wen-Ting
Yang, Shyh-Chyun
Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title_full Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title_fullStr Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title_full_unstemmed Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title_short Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
title_sort platinum-catalyzed allylation of 2,3-disubstituted indoles with allylic acetates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149942/
https://www.ncbi.nlm.nih.gov/pubmed/29186044
http://dx.doi.org/10.3390/molecules22122097
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