Cargando…

Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives by the Reaction of Malononitrile, Aldehydes and 2-Oxoglyoxalarylhydrazones in Q-Tubes

Efficient synthesis of phenanthridin-6(5H)-one derivatives 12a–n in a four-component reaction of aldehyde hydrazone, aromatic aldehydes and malononitrile in Q-Tubes is reported. The results showed that the methodology has the advantage of being a one-pot synthesis of tricyclic systems in good yields...

Descripción completa

Detalles Bibliográficos
Autores principales:	AL-Johani, Majdah A., Al-Zaydi, Khadijah M., Mousally, Sameera M., Alqahtani, Norah F., Elnagdi, Noha Hilmy, Elnagdi, Mohamed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149974/ https://www.ncbi.nlm.nih.gov/pubmed/29194410 http://dx.doi.org/10.3390/molecules22122114

Ejemplares similares

Reassignment of the Structures of Products Produced by Reactions of the Product Believed To Be 2-(1-Phenyl-2-Thiocyanatoethylidene)-malononitrile with Electrophiles
por: Al-Mousawi, Saleh Mohammed, et al.
Publicado: (2011)

Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines
por: Moustafa, Moustafa Sherief, et al.
Publicado: (2012)

Enaminones as Building Blocks in Heterocyclic Syntheses: Reinvestigating the Product Structures of Enaminones with Malononitrile. A Novel Route to 6-Substituted-3-Oxo-2,3-Dihydropyridazine-4-Carboxylic Acids
por: Alnajjar, Abdul-aziz, et al.
Publicado: (2008)

2-Arylhydrazonopropanals as Building Blocks in Heterocyclic Chemistry: Microwave Assisted Condensation of 2-Aryl-hydrazonopropanals with Amines and Active Methylene Reagents
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2003)

Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans
por: Elnagdi, Noha M. Hilmy, et al.
Publicado: (2012)

Glycerol and Q-Tubes: Green Catalyst and Technique for Synthesis of Polyfunctionally Substituted Heteroaromatics and Anilines
por: AlMarzouq, Douaa Salman, et al.
Publicado: (2019)

Sonochemical Degradation of Benzothiophene (BT) in Deionized Water, Natural Water and Sea Water
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2019)

Organobase-catalyzed three-component reactions for the synthesis of 4H-2-aminopyrans, condensed pyrans and polysubstituted benzenes
por: Moustafa, Moustafa Sherief, et al.
Publicado: (2014)

Studies with Azinylacetonitriles: 2-Pyridylacetonitrile as a Precursor to Functionally Substituted Pyridines
por: Al-Sheikh, Mariam Abdullah, et al.
Publicado: (2009)

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating
por: Sadek, Kamal Usef, et al.
Publicado: (2012)

Microwave Assisted Dyeing of Polyester Fabrics with Disperse Dyes
por: Al-Mousawi, Saleh Mohammed, et al.
Publicado: (2013)

Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and N-substituted 2-cyanoacetamide
por: Vala, Ruturajsinh M., et al.
Publicado: (2019)

Deeper Insight into the Six‐Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products
por: Bock, Christina M., et al.
Publicado: (2017)

Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines
por: Al-Mousawi, Saleh M., et al.
Publicado: (2009)

Studies on 3-Oxoalkanenitriles: Novel Rearrangement Reactions Observed in Studies of the Chemistry of 3-Heteroaroyl-3-Oxoalkanenitriles as Novel Routes to 2-Dialkylaminopyridines
por: Al-Matar, Hamad M., et al.
Publicado: (2012)

A Novel Synthesis of Highly Functionalized Pyridines by a One-Pot, Three-Component Tandem Reaction of Aldehydes, Malononitrile and N-Alkyl-2-cyanoacetamides under Microwave Irradiation
por: Mekheimer, Ramadan Ahmed, et al.
Publicado: (2018)

Stereoselective Synthesis of Multisubstituted Cyclohexanes by Reaction of Conjugated Enynones with Malononitrile in the Presence of LDA
por: Igushkina, Anastasiya V., et al.
Publicado: (2020)

Composites of Palladium–Nickel Alloy Nanoparticles and Graphene Oxide for the Knoevenagel Condensation of Aldehydes with Malononitrile
por: Lolak, Nabih, et al.
Publicado: (2019)

Green and Highly Efficient Synthesis of 2-Arylbenzothiazoles Using Glycerol without Catalyst at Ambient Temperature
por: Sadek, Kamal Usef, et al.
Publicado: (2012)

Back Cover: Deeper Insight into the Six‐Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products (ChemistryOpen 3/2017)
por: Bock, Christina M., et al.
Publicado: (2017)

Correction to “Composites of Palladium–Nickel Alloy Nanoparticles and Graphene Oxide for the Knoevenagel Condensation of Aldehydes with Malononitrile”
por: Lolak, Nabih, et al.
Publicado: (2020)

Gram-Scale Synthesis of 1,8-Naphthyridines in Water: The Friedlander Reaction Revisited
por: Choudhury, Shubhranshu Shekhar, et al.
Publicado: (2021)

Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
por: Zaky, Omniya Sayed, et al.
Publicado: (2012)

Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
por: Al-Zaydi, Khadijah M., et al.
Publicado: (2023)

Microwave Assisted Synthesis, Part 1: Rapid Solventless Synthesis of 3-Substituted Coumarins and Benzocoumarins by Microwave Irradiation of the Corresponding Enaminones
por: Al-Zaydi, Khadijah M.
Publicado: (2003)

Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile
por: Sun, Jing, et al.
Publicado: (2017)

A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
por: Helmy, Noha M., et al.
Publicado: (2011)

Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
por: Riyadh, Sayed M., et al.
Publicado: (2008)

Synthesis of 1,8-Naphthyridines by the Ionic Liquid-Catalyzed Friedlander Reaction and Application in Corrosion Inhibition
por: San, Ying, et al.
Publicado: (2021)

Enaminones in Heterocyclic Synthesis: A Novel Route to Tetrahydropyrimidines, Dihydropyridines, Triacylbenzenes and Naphthofurans under Microwave Irradiation
por: Al-Mousawi, S.M., et al.
Publicado: (2009)

Cytotoxic Evaluation of Some Fused Pyridazino- and Pyrrolo-quinazolinones Derivatives on Melanoma and Prostate Cell Lines
por: Vaseghi, Golnaz, et al.
Publicado: (2017)

Hydrogen Transfer-Mediated Multicomponent Reaction for Direct Synthesis of Quinazolines by a Naphthyridine-Based Iridium Catalyst
por: Tan, Zhenda, et al.
Publicado: (2020)

Reaction of benzoxasilocines with aromatic aldehydes: Synthesis of homopterocarpans
por: Álvarez-Corral, Míriam, et al.
Publicado: (2007)

The Prognostic Value of the Aldehyde Reaction in Kala-Azar
por: Chopra, R. N., et al.
Publicado: (1932)

The Photochemistry of Benzotriazole Derivatives. Part 2: Photolysis of 1-Substituted Benzotriazole Arylhydrazones: New Route to Phenanthridin-6-yl-2-phenyldiazines
por: Al-Jalal, Nader A., et al.
Publicado: (2011)

Unnatural imidazopyridopyrimidine:naphthyridine base pairs: selective incorporation and extension reaction by Deep Vent (exo(−) ) DNA polymerase
por: Ogata, Shintaro, et al.
Publicado: (2009)

Green One Pot Solvent-Free Synthesis of Pyrano[2,3-c]-Pyrazoles and Pyrazolo[1,5-a]Pyrimidines
por: Al-Matar, Hamad M., et al.
Publicado: (2010)

Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents
por: Ibrahim, Hamada Mohamed, et al.
Publicado: (2013)

Efficient Routes to Pyrazolo[3,4-e][1,2,4]triazines and a New Ring System: [1,2,4]Triazino[5,6-d][1,2,3]triazines
por: Al-Matar, Hamad Mohamed, et al.
Publicado: (2010)

Aldehyde Oxidase: Reaction Mechanism and Prediction of Site of Metabolism
por: Montefiori, Marco, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a6sb8viq554occns6lf424fh4i