FAK family kinases: The Yin and Yang of cancer cell invasiveness

Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2...

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Detalles Bibliográficos
Autores principales: Genna, Alessandro, Gil-Henn, Hava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149990/
https://www.ncbi.nlm.nih.gov/pubmed/30250911
http://dx.doi.org/10.1080/23723556.2018.1449584
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author Genna, Alessandro
Gil-Henn, Hava
author_facet Genna, Alessandro
Gil-Henn, Hava
author_sort Genna, Alessandro
collection PubMed
description Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.
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spelling pubmed-61499902019-05-25 FAK family kinases: The Yin and Yang of cancer cell invasiveness Genna, Alessandro Gil-Henn, Hava Mol Cell Oncol Author's Views Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis. Taylor & Francis 2018-05-25 /pmc/articles/PMC6149990/ /pubmed/30250911 http://dx.doi.org/10.1080/23723556.2018.1449584 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Genna, Alessandro
Gil-Henn, Hava
FAK family kinases: The Yin and Yang of cancer cell invasiveness
title FAK family kinases: The Yin and Yang of cancer cell invasiveness
title_full FAK family kinases: The Yin and Yang of cancer cell invasiveness
title_fullStr FAK family kinases: The Yin and Yang of cancer cell invasiveness
title_full_unstemmed FAK family kinases: The Yin and Yang of cancer cell invasiveness
title_short FAK family kinases: The Yin and Yang of cancer cell invasiveness
title_sort fak family kinases: the yin and yang of cancer cell invasiveness
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149990/
https://www.ncbi.nlm.nih.gov/pubmed/30250911
http://dx.doi.org/10.1080/23723556.2018.1449584
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