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Support for Natural Small-Molecule Phenols as Anxiolytics

Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting the hypothesis that NSMPs are generally anxiolytic. The anxiolytic activities of seven simple phenols, including...

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Autores principales: Wang, Xiaohong, Chen, Yahong, Wang, Qiang, Sun, Lu, Li, Guiyun, Zhang, Chanxi, Huang, Jianmei, Chen, Lei, Zhai, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150002/
https://www.ncbi.nlm.nih.gov/pubmed/29210995
http://dx.doi.org/10.3390/molecules22122138
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author Wang, Xiaohong
Chen, Yahong
Wang, Qiang
Sun, Lu
Li, Guiyun
Zhang, Chanxi
Huang, Jianmei
Chen, Lei
Zhai, Haifeng
author_facet Wang, Xiaohong
Chen, Yahong
Wang, Qiang
Sun, Lu
Li, Guiyun
Zhang, Chanxi
Huang, Jianmei
Chen, Lei
Zhai, Haifeng
author_sort Wang, Xiaohong
collection PubMed
description Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting the hypothesis that NSMPs are generally anxiolytic. The anxiolytic activities of seven simple phenols, including phloroglucinol, eugenol, protocatechuic aldehyde, vanillin, thymol, ferulic acid, and caffeic acid, were assayed with the elevated plus maze (EPM) test in mice. The oral doses were 5, 10 and 20 mg/kg, except for phloroglucinol for which the doses were 2.5, 5 and 10 mg/kg. All tested phenols had anxiolytic activity in mice. The phenolic hydroxyl group in 4-hydroxycinnamic acid (4-OH CA) was essential for the anxiolytic activity in the EPM test in mice and rats compared to 4-chlorocinnamic acid (4-Cl CA). The in vivo spike recording of rats’ hippocampal neurons also showed significant differences between 4-OH CA and 4-Cl CA. Behavioral and neuronal spike recording results converged to indicate the hippocampal CA1 region might be a part of the anxiolytic pathways of 4-OH CA. Therefore, our study provides further experimental data supporting NSMPs sharing anxiolytic activity, which may have general implications for phytotherapy because small phenols occur extensively in herbal medicines.
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spelling pubmed-61500022018-11-13 Support for Natural Small-Molecule Phenols as Anxiolytics Wang, Xiaohong Chen, Yahong Wang, Qiang Sun, Lu Li, Guiyun Zhang, Chanxi Huang, Jianmei Chen, Lei Zhai, Haifeng Molecules Article Natural small-molecule phenols (NSMPs) share some bioactivities. The anxiolytic activity of NSMPs is attracting attention in the scientific community. This paper provides data supporting the hypothesis that NSMPs are generally anxiolytic. The anxiolytic activities of seven simple phenols, including phloroglucinol, eugenol, protocatechuic aldehyde, vanillin, thymol, ferulic acid, and caffeic acid, were assayed with the elevated plus maze (EPM) test in mice. The oral doses were 5, 10 and 20 mg/kg, except for phloroglucinol for which the doses were 2.5, 5 and 10 mg/kg. All tested phenols had anxiolytic activity in mice. The phenolic hydroxyl group in 4-hydroxycinnamic acid (4-OH CA) was essential for the anxiolytic activity in the EPM test in mice and rats compared to 4-chlorocinnamic acid (4-Cl CA). The in vivo spike recording of rats’ hippocampal neurons also showed significant differences between 4-OH CA and 4-Cl CA. Behavioral and neuronal spike recording results converged to indicate the hippocampal CA1 region might be a part of the anxiolytic pathways of 4-OH CA. Therefore, our study provides further experimental data supporting NSMPs sharing anxiolytic activity, which may have general implications for phytotherapy because small phenols occur extensively in herbal medicines. MDPI 2017-12-06 /pmc/articles/PMC6150002/ /pubmed/29210995 http://dx.doi.org/10.3390/molecules22122138 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xiaohong
Chen, Yahong
Wang, Qiang
Sun, Lu
Li, Guiyun
Zhang, Chanxi
Huang, Jianmei
Chen, Lei
Zhai, Haifeng
Support for Natural Small-Molecule Phenols as Anxiolytics
title Support for Natural Small-Molecule Phenols as Anxiolytics
title_full Support for Natural Small-Molecule Phenols as Anxiolytics
title_fullStr Support for Natural Small-Molecule Phenols as Anxiolytics
title_full_unstemmed Support for Natural Small-Molecule Phenols as Anxiolytics
title_short Support for Natural Small-Molecule Phenols as Anxiolytics
title_sort support for natural small-molecule phenols as anxiolytics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150002/
https://www.ncbi.nlm.nih.gov/pubmed/29210995
http://dx.doi.org/10.3390/molecules22122138
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