LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation o...

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Detalles Bibliográficos
Autores principales: Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150006/
https://www.ncbi.nlm.nih.gov/pubmed/30250927
http://dx.doi.org/10.1080/23723556.2018.1481813
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author Maiques-Diaz, Alba
Lynch, James T.
Spencer, Gary J.
Somervaille, Tim C.P.
author_facet Maiques-Diaz, Alba
Lynch, James T.
Spencer, Gary J.
Somervaille, Tim C.P.
author_sort Maiques-Diaz, Alba
collection PubMed
description Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
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spelling pubmed-61500062019-08-01 LSD1 inhibitors disrupt the GFI1 transcription repressor complex Maiques-Diaz, Alba Lynch, James T. Spencer, Gary J. Somervaille, Tim C.P. Mol Cell Oncol Author's Views Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation. Taylor & Francis 2018-08-01 /pmc/articles/PMC6150006/ /pubmed/30250927 http://dx.doi.org/10.1080/23723556.2018.1481813 Text en © 2018 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Maiques-Diaz, Alba
Lynch, James T.
Spencer, Gary J.
Somervaille, Tim C.P.
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title_full LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title_fullStr LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title_full_unstemmed LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title_short LSD1 inhibitors disrupt the GFI1 transcription repressor complex
title_sort lsd1 inhibitors disrupt the gfi1 transcription repressor complex
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150006/
https://www.ncbi.nlm.nih.gov/pubmed/30250927
http://dx.doi.org/10.1080/23723556.2018.1481813
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