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The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents

The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions...

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Autores principales: Pantic, Jelena M., Jovanovic, Ivan P., Radosavljevic, Gordana D., Arsenijevic, Nebojsa N., Conlon, J. Michael, Lukic, Miodrag L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150033/
https://www.ncbi.nlm.nih.gov/pubmed/29236056
http://dx.doi.org/10.3390/molecules22122071
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author Pantic, Jelena M.
Jovanovic, Ivan P.
Radosavljevic, Gordana D.
Arsenijevic, Nebojsa N.
Conlon, J. Michael
Lukic, Miodrag L.
author_facet Pantic, Jelena M.
Jovanovic, Ivan P.
Radosavljevic, Gordana D.
Arsenijevic, Nebojsa N.
Conlon, J. Michael
Lukic, Miodrag L.
author_sort Pantic, Jelena M.
collection PubMed
description The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions of a range of species belonging to the families Alytidae, Ascaphidae, Discoglossidae, Leptodactylidae, Pipidae and Ranidae. Their effects upon production of inflammatory and immunoregulatory cytokines by target cells have been evaluated ex vivo and effects upon cytokine expression and immune cell activity have been studied in vivo by flow cytometry after injection into mice. The naturally-occurring peptides and/or their synthetic analogues show complex and variable actions on the production of proinflammatory (TNF-α, IL-1β, IL-12, IL-23, IL-8, IFN-γ and IL-17), pleiotropic (IL-4 and IL-6) and immunosuppressive (IL-10 and TGF-β) cytokines by peripheral and spleen cells, peritoneal cells and/or isolated macrophages. The effects of frenatin 2.1S include enhancement of the activation state and homing capacity of Th1-type lymphocytes and NK cells in the mouse peritoneal cavity, as well as the promotion of their tumoricidal capacities. Overall, the diverse effects of frog skin-derived peptides on the immune system indicate their potential for development into therapeutic agents.
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spelling pubmed-61500332018-11-13 The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents Pantic, Jelena M. Jovanovic, Ivan P. Radosavljevic, Gordana D. Arsenijevic, Nebojsa N. Conlon, J. Michael Lukic, Miodrag L. Molecules Review The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions of a range of species belonging to the families Alytidae, Ascaphidae, Discoglossidae, Leptodactylidae, Pipidae and Ranidae. Their effects upon production of inflammatory and immunoregulatory cytokines by target cells have been evaluated ex vivo and effects upon cytokine expression and immune cell activity have been studied in vivo by flow cytometry after injection into mice. The naturally-occurring peptides and/or their synthetic analogues show complex and variable actions on the production of proinflammatory (TNF-α, IL-1β, IL-12, IL-23, IL-8, IFN-γ and IL-17), pleiotropic (IL-4 and IL-6) and immunosuppressive (IL-10 and TGF-β) cytokines by peripheral and spleen cells, peritoneal cells and/or isolated macrophages. The effects of frenatin 2.1S include enhancement of the activation state and homing capacity of Th1-type lymphocytes and NK cells in the mouse peritoneal cavity, as well as the promotion of their tumoricidal capacities. Overall, the diverse effects of frog skin-derived peptides on the immune system indicate their potential for development into therapeutic agents. MDPI 2017-12-13 /pmc/articles/PMC6150033/ /pubmed/29236056 http://dx.doi.org/10.3390/molecules22122071 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pantic, Jelena M.
Jovanovic, Ivan P.
Radosavljevic, Gordana D.
Arsenijevic, Nebojsa N.
Conlon, J. Michael
Lukic, Miodrag L.
The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title_full The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title_fullStr The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title_full_unstemmed The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title_short The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
title_sort potential of frog skin-derived peptides for development into therapeutically-valuable immunomodulatory agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150033/
https://www.ncbi.nlm.nih.gov/pubmed/29236056
http://dx.doi.org/10.3390/molecules22122071
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