ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer

The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mishra, Prachi, Tang, Wei, Ambs, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150044/
https://www.ncbi.nlm.nih.gov/pubmed/30250890
http://dx.doi.org/10.1080/23723556.2018.1432260
_version_ 1783356921918521344
author Mishra, Prachi
Tang, Wei
Ambs, Stefan
author_facet Mishra, Prachi
Tang, Wei
Ambs, Stefan
author_sort Mishra, Prachi
collection PubMed
description The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.
format Online
Article
Text
id pubmed-6150044
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-61500442019-04-19 ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer Mishra, Prachi Tang, Wei Ambs, Stefan Mol Cell Oncol Author's Views The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis. Taylor & Francis 2018-04-19 /pmc/articles/PMC6150044/ /pubmed/30250890 http://dx.doi.org/10.1080/23723556.2018.1432260 Text en This article not subject to U.S. copyright law http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Mishra, Prachi
Tang, Wei
Ambs, Stefan
ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title_full ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title_fullStr ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title_full_unstemmed ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title_short ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
title_sort adhfe1 is a myc-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150044/
https://www.ncbi.nlm.nih.gov/pubmed/30250890
http://dx.doi.org/10.1080/23723556.2018.1432260
work_keys_str_mv AT mishraprachi adhfe1isamyclinkedoncogenethatinducesmetabolicreprogrammingandcellulardedifferentiationinbreastcancer
AT tangwei adhfe1isamyclinkedoncogenethatinducesmetabolicreprogrammingandcellulardedifferentiationinbreastcancer
AT ambsstefan adhfe1isamyclinkedoncogenethatinducesmetabolicreprogrammingandcellulardedifferentiationinbreastcancer

Ejemplares similares