The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis

Non-alcoholic Fatty Liver Disease (NAFLD) is becoming the leading cause of chronic liver injury in developed countries and China. Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis (SS) toward higher risk nonalcoholic steatohepati...

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Autores principales: Chen, Yaxi, Varghese, Zac, Ruan, Xiong Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150078/
https://www.ncbi.nlm.nih.gov/pubmed/30258859
http://dx.doi.org/10.1016/j.gendis.2014.07.007
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author Chen, Yaxi
Varghese, Zac
Ruan, Xiong Z.
author_facet Chen, Yaxi
Varghese, Zac
Ruan, Xiong Z.
author_sort Chen, Yaxi
collection PubMed
description Non-alcoholic Fatty Liver Disease (NAFLD) is becoming the leading cause of chronic liver injury in developed countries and China. Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis (SS) toward higher risk nonalcoholic steatohepatitis (NASH) states. However, the exact mechanisms by which inflammation leading to NASH are incompletely understood. In this review, we focus the role of the cross talk between inflammation and lipid homeostasis on the progression of NAFLD.
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spelling pubmed-61500782018-09-26 The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis Chen, Yaxi Varghese, Zac Ruan, Xiong Z. Genes Dis Article Non-alcoholic Fatty Liver Disease (NAFLD) is becoming the leading cause of chronic liver injury in developed countries and China. Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis (SS) toward higher risk nonalcoholic steatohepatitis (NASH) states. However, the exact mechanisms by which inflammation leading to NASH are incompletely understood. In this review, we focus the role of the cross talk between inflammation and lipid homeostasis on the progression of NAFLD. Chongqing Medical University 2014-07-27 /pmc/articles/PMC6150078/ /pubmed/30258859 http://dx.doi.org/10.1016/j.gendis.2014.07.007 Text en Copyright © 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Chen, Yaxi
Varghese, Zac
Ruan, Xiong Z.
The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title_full The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title_fullStr The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title_full_unstemmed The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title_short The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
title_sort molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150078/
https://www.ncbi.nlm.nih.gov/pubmed/30258859
http://dx.doi.org/10.1016/j.gendis.2014.07.007
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