Clostridium novyi-NT in cancer therapy

The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and...

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Autores principales: Staedtke, Verena, Roberts, Nicholas J., Bai, Ren-Yuan, Zhou, Shibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150096/
https://www.ncbi.nlm.nih.gov/pubmed/30258882
http://dx.doi.org/10.1016/j.gendis.2016.01.003
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author Staedtke, Verena
Roberts, Nicholas J.
Bai, Ren-Yuan
Zhou, Shibin
author_facet Staedtke, Verena
Roberts, Nicholas J.
Bai, Ren-Yuan
Zhou, Shibin
author_sort Staedtke, Verena
collection PubMed
description The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of C. novyi-NT therapy, key challenges and limitations, and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches, to establish C. novyi-NT as an essential tool in cancer therapy.
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spelling pubmed-61500962018-09-26 Clostridium novyi-NT in cancer therapy Staedtke, Verena Roberts, Nicholas J. Bai, Ren-Yuan Zhou, Shibin Genes Dis Article The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of C. novyi-NT therapy, key challenges and limitations, and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches, to establish C. novyi-NT as an essential tool in cancer therapy. Chongqing Medical University 2016-02-06 /pmc/articles/PMC6150096/ /pubmed/30258882 http://dx.doi.org/10.1016/j.gendis.2016.01.003 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Staedtke, Verena
Roberts, Nicholas J.
Bai, Ren-Yuan
Zhou, Shibin
Clostridium novyi-NT in cancer therapy
title Clostridium novyi-NT in cancer therapy
title_full Clostridium novyi-NT in cancer therapy
title_fullStr Clostridium novyi-NT in cancer therapy
title_full_unstemmed Clostridium novyi-NT in cancer therapy
title_short Clostridium novyi-NT in cancer therapy
title_sort clostridium novyi-nt in cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150096/
https://www.ncbi.nlm.nih.gov/pubmed/30258882
http://dx.doi.org/10.1016/j.gendis.2016.01.003
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AT zhoushibin clostridiumnovyintincancertherapy

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