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Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region

X-linked red–green color blindness is the most widespread form of vision impairment. The study aimed to determine the prevalence and gene frequencies of red–green color vision impairments among children of six different human populations of Jammu province. A total of 1028 healthy subjects (6–15 year...

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Autores principales: Fareed, Mohd, Anwar, Malik Azeem, Afzal, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150100/
https://www.ncbi.nlm.nih.gov/pubmed/30258865
http://dx.doi.org/10.1016/j.gendis.2015.02.006
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author Fareed, Mohd
Anwar, Malik Azeem
Afzal, Mohammad
author_facet Fareed, Mohd
Anwar, Malik Azeem
Afzal, Mohammad
author_sort Fareed, Mohd
collection PubMed
description X-linked red–green color blindness is the most widespread form of vision impairment. The study aimed to determine the prevalence and gene frequencies of red–green color vision impairments among children of six different human populations of Jammu province. A total of 1028 healthy subjects (6–15 years of age) were selected from five Muslim populations and the color vision impairments were determined using the Ishihara's test of color deficiency. The gene frequency was calculated using Hardy–Weinberg equilibrium method. The prevalence of color vision deficiency (CVD) ranged from 5.26% to 11.36% among males and 0.00%–3.03% among females of six different populations. The gender based differences in the frequency of CVD was found to be statistically significant (p < 0.0001), with a higher prevalence among male (7.52%) as compared to female (0.83%) children. We observed high frequency of deutan as compared to protan defects. The incidences of deuteranomaly (5.68%) and deuteranopia (2.27%) were higher among male children of Syed population while the frequencies of protanomaly (1.94%), protanopia (1.28%) and achromacy (2.27%) were the highest among male subjects of Khan, Malik and Syed populations, respectively. The allele and genotype frequencies showed cogent differences among six populations. The population based assessment of CVDs help patients to follow adaptive strategies that could minimize the risks of the disease.
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spelling pubmed-61501002018-09-26 Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region Fareed, Mohd Anwar, Malik Azeem Afzal, Mohammad Genes Dis Article X-linked red–green color blindness is the most widespread form of vision impairment. The study aimed to determine the prevalence and gene frequencies of red–green color vision impairments among children of six different human populations of Jammu province. A total of 1028 healthy subjects (6–15 years of age) were selected from five Muslim populations and the color vision impairments were determined using the Ishihara's test of color deficiency. The gene frequency was calculated using Hardy–Weinberg equilibrium method. The prevalence of color vision deficiency (CVD) ranged from 5.26% to 11.36% among males and 0.00%–3.03% among females of six different populations. The gender based differences in the frequency of CVD was found to be statistically significant (p < 0.0001), with a higher prevalence among male (7.52%) as compared to female (0.83%) children. We observed high frequency of deutan as compared to protan defects. The incidences of deuteranomaly (5.68%) and deuteranopia (2.27%) were higher among male children of Syed population while the frequencies of protanomaly (1.94%), protanopia (1.28%) and achromacy (2.27%) were the highest among male subjects of Khan, Malik and Syed populations, respectively. The allele and genotype frequencies showed cogent differences among six populations. The population based assessment of CVDs help patients to follow adaptive strategies that could minimize the risks of the disease. Chongqing Medical University 2015-02-25 /pmc/articles/PMC6150100/ /pubmed/30258865 http://dx.doi.org/10.1016/j.gendis.2015.02.006 Text en Copyright © 2015, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Fareed, Mohd
Anwar, Malik Azeem
Afzal, Mohammad
Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title_full Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title_fullStr Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title_full_unstemmed Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title_short Prevalence and gene frequency of color vision impairments among children of six populations from North Indian region
title_sort prevalence and gene frequency of color vision impairments among children of six populations from north indian region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150100/
https://www.ncbi.nlm.nih.gov/pubmed/30258865
http://dx.doi.org/10.1016/j.gendis.2015.02.006
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