New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity

Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Mingxiao, Qi, Zheyuan, Hao, Yimeng, Lv, Chongning, Jia, Lingyun, Wang, Jing, Lu, Jincai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150161/
https://www.ncbi.nlm.nih.gov/pubmed/29099046
http://dx.doi.org/10.3390/molecules22111859
Descripción
Sumario:Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC(50) ranging from 24.84 to 37.22 μmol L(−1), which was capable for further drug exploration.

Ejemplares similares