New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity

Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against...

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Detalles Bibliográficos
Autores principales: Li, Mingxiao, Qi, Zheyuan, Hao, Yimeng, Lv, Chongning, Jia, Lingyun, Wang, Jing, Lu, Jincai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150161/
https://www.ncbi.nlm.nih.gov/pubmed/29099046
http://dx.doi.org/10.3390/molecules22111859
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author Li, Mingxiao
Qi, Zheyuan
Hao, Yimeng
Lv, Chongning
Jia, Lingyun
Wang, Jing
Lu, Jincai
author_facet Li, Mingxiao
Qi, Zheyuan
Hao, Yimeng
Lv, Chongning
Jia, Lingyun
Wang, Jing
Lu, Jincai
author_sort Li, Mingxiao
collection PubMed
description Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC(50) ranging from 24.84 to 37.22 μmol L(−1), which was capable for further drug exploration.
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spelling pubmed-61501612018-11-13 New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity Li, Mingxiao Qi, Zheyuan Hao, Yimeng Lv, Chongning Jia, Lingyun Wang, Jing Lu, Jincai Molecules Article Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC(50) ranging from 24.84 to 37.22 μmol L(−1), which was capable for further drug exploration. MDPI 2017-11-02 /pmc/articles/PMC6150161/ /pubmed/29099046 http://dx.doi.org/10.3390/molecules22111859 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Mingxiao
Qi, Zheyuan
Hao, Yimeng
Lv, Chongning
Jia, Lingyun
Wang, Jing
Lu, Jincai
New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title_full New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title_fullStr New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title_full_unstemmed New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title_short New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity
title_sort new adducts of iriflophene and flavonoids isolated from sedum aizoon l. with potential antitumor activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150161/
https://www.ncbi.nlm.nih.gov/pubmed/29099046
http://dx.doi.org/10.3390/molecules22111859
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