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Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour

Giant cell tumours (GCT) of the finger phalanges are extremely rare but have a high rate of recurrence. This report details the case of a GCT of the proximal phalanx of the fourth finger in a 64-year-old man. The patient was initially subjected to systemic neoadjuvant denosumab treatment, and subseq...

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Autor principal: Beltrami, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150168/
https://www.ncbi.nlm.nih.gov/pubmed/30232071
http://dx.doi.org/10.1136/bcr-2018-226007
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author Beltrami, Giovanni
author_facet Beltrami, Giovanni
author_sort Beltrami, Giovanni
collection PubMed
description Giant cell tumours (GCT) of the finger phalanges are extremely rare but have a high rate of recurrence. This report details the case of a GCT of the proximal phalanx of the fourth finger in a 64-year-old man. The patient was initially subjected to systemic neoadjuvant denosumab treatment, and subsequent aggressive curettage, sparing of the articular joints, local cryotherapy and autologous intercalary fibular bone graft. Finger function after surgery was considered satisfactory, despite limited proximal interphalangeal (PIP) joint motion. Aggressive local GCT recurrence was noted at the 32-month follow-up, with entire articular and diaphyseal phalangeal destruction. The patient refused amputation and, after analysing several reconstruction options, he was treated by entire en bloc resection and reconstruction employing a 3D-printed custom titanium implant. At the 24-month follow-up, the patient is free of disease and pain, and has a stable finger, good metacarpal–phalangeal joint motion, fusion of the PIP joint, a good Musculoskeletal Tumour Society score, and functional ability.
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spelling pubmed-61501682018-09-26 Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour Beltrami, Giovanni BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Giant cell tumours (GCT) of the finger phalanges are extremely rare but have a high rate of recurrence. This report details the case of a GCT of the proximal phalanx of the fourth finger in a 64-year-old man. The patient was initially subjected to systemic neoadjuvant denosumab treatment, and subsequent aggressive curettage, sparing of the articular joints, local cryotherapy and autologous intercalary fibular bone graft. Finger function after surgery was considered satisfactory, despite limited proximal interphalangeal (PIP) joint motion. Aggressive local GCT recurrence was noted at the 32-month follow-up, with entire articular and diaphyseal phalangeal destruction. The patient refused amputation and, after analysing several reconstruction options, he was treated by entire en bloc resection and reconstruction employing a 3D-printed custom titanium implant. At the 24-month follow-up, the patient is free of disease and pain, and has a stable finger, good metacarpal–phalangeal joint motion, fusion of the PIP joint, a good Musculoskeletal Tumour Society score, and functional ability. BMJ Publishing Group 2018-09-18 /pmc/articles/PMC6150168/ /pubmed/30232071 http://dx.doi.org/10.1136/bcr-2018-226007 Text en © BMJ Publishing Group Limited 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Beltrami, Giovanni
Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title_full Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title_fullStr Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title_full_unstemmed Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title_short Custom 3D-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
title_sort custom 3d-printed finger proximal phalanx as salvage of limb function after aggressive recurrence of giant cell tumour
topic Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150168/
https://www.ncbi.nlm.nih.gov/pubmed/30232071
http://dx.doi.org/10.1136/bcr-2018-226007
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