Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis

We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: −28 to 46 ms) in the fluconazole treatment group and −12.6 ms (IQR: −39 to 13.5 ms) in those not taking fluconazole (P = 0...

Descripción completa

Detalles Bibliográficos
Autores principales: Molloy, Síle F., Bradley, John, Karunaharan, Natasha, Mputu, Muhammad, Stone, Neil, Phulusa, Jacob, Chawinga, Chimwemwe, Gaskell, Kate, Segula, Dalitso, Ming, Damien, Peirse, Mary, Chanda, Duncan, Lakhi, Shabir, Loyse, Angela, Kanyama, Cecilia, Heyderman, Robert S., Harrison, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150187/
https://www.ncbi.nlm.nih.gov/pubmed/30102652
http://dx.doi.org/10.1097/QAD.0000000000001961
Descripción
Sumario:We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: −28 to 46 ms) in the fluconazole treatment group and −12.6 ms (IQR: −39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.

Ejemplares similares