A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters

A new synthetic approach to polyfunctional hexahydropyrrolo[3,4-b]pyrroles was developed based on cyclization of N-arylbromomaleimides with aminocrotonic acid esters. A highly chemo- and stereoselective reaction is a Hantzsch-type domino process, involving the steps of initial nucleophilic C-additio...

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Detalles Bibliográficos
Autores principales: Shikhaliev, Khidmet, Sabynin, Artem, Sekirin, Valeri, Krysin, Michael, Zubkov, Fedor, Yankina, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150208/
https://www.ncbi.nlm.nih.gov/pubmed/29165400
http://dx.doi.org/10.3390/molecules22112035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150208/
https://www.ncbi.nlm.nih.gov/pubmed/29165400
http://dx.doi.org/10.3390/molecules22112035

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