Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents

We designed and synthesized 26 prototype compounds and studied their anti-inflammatory activity and underlying molecular mechanisms. The inhibitory effects of the compounds on the production of nitric oxide (NO), cytokines, inflammatory-related proteins, and mRNAs in lipopolysaccharide (LPS)-stimula...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Luo, Lu, Han, Chao, Lv, Handeng, Chen, Di, Shen, Guoliang, Wu, Kaiqi, Pan, Suwei, Ye, Faqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150211/
https://www.ncbi.nlm.nih.gov/pubmed/29137170
http://dx.doi.org/10.3390/molecules22111960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150211/
https://www.ncbi.nlm.nih.gov/pubmed/29137170
http://dx.doi.org/10.3390/molecules22111960

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