Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus

Four new para-benzoquinone containing abietane-type diterpenoids (1–4) along with thirteen known diterpenoids (5–17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The co...

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Detalles Bibliográficos
Autores principales: Abdissa, Negera, Frese, Marcel, Sewald, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150224/
https://www.ncbi.nlm.nih.gov/pubmed/29112171
http://dx.doi.org/10.3390/molecules22111919
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author Abdissa, Negera
Frese, Marcel
Sewald, Norbert
author_facet Abdissa, Negera
Frese, Marcel
Sewald, Norbert
author_sort Abdissa, Negera
collection PubMed
description Four new para-benzoquinone containing abietane-type diterpenoids (1–4) along with thirteen known diterpenoids (5–17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin.
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spelling pubmed-61502242018-11-13 Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus Abdissa, Negera Frese, Marcel Sewald, Norbert Molecules Article Four new para-benzoquinone containing abietane-type diterpenoids (1–4) along with thirteen known diterpenoids (5–17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin. MDPI 2017-11-07 /pmc/articles/PMC6150224/ /pubmed/29112171 http://dx.doi.org/10.3390/molecules22111919 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdissa, Negera
Frese, Marcel
Sewald, Norbert
Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title_full Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title_fullStr Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title_full_unstemmed Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title_short Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus
title_sort antimicrobial abietane-type diterpenoids from plectranthus punctatus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150224/
https://www.ncbi.nlm.nih.gov/pubmed/29112171
http://dx.doi.org/10.3390/molecules22111919
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AT fresemarcel antimicrobialabietanetypediterpenoidsfromplectranthuspunctatus
AT sewaldnorbert antimicrobialabietanetypediterpenoidsfromplectranthuspunctatus

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