A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis

A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M(2) (5) and schizandrin (6) were isolated from the f...

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Autores principales: Li, Fenghua, Zhang, Ting, Sun, Hua, Gu, Haifeng, Wang, Hongqing, Su, Xianming, Li, Changkang, Li, Baoming, Chen, Ruoyun, Kang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150265/
https://www.ncbi.nlm.nih.gov/pubmed/29125562
http://dx.doi.org/10.3390/molecules22111931
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author Li, Fenghua
Zhang, Ting
Sun, Hua
Gu, Haifeng
Wang, Hongqing
Su, Xianming
Li, Changkang
Li, Baoming
Chen, Ruoyun
Kang, Jie
author_facet Li, Fenghua
Zhang, Ting
Sun, Hua
Gu, Haifeng
Wang, Hongqing
Su, Xianming
Li, Changkang
Li, Baoming
Chen, Ruoyun
Kang, Jie
author_sort Li, Fenghua
collection PubMed
description A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M(2) (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4–6 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells.
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spelling pubmed-61502652018-11-13 A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis Li, Fenghua Zhang, Ting Sun, Hua Gu, Haifeng Wang, Hongqing Su, Xianming Li, Changkang Li, Baoming Chen, Ruoyun Kang, Jie Molecules Article A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M(2) (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4–6 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells. MDPI 2017-11-10 /pmc/articles/PMC6150265/ /pubmed/29125562 http://dx.doi.org/10.3390/molecules22111931 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Fenghua
Zhang, Ting
Sun, Hua
Gu, Haifeng
Wang, Hongqing
Su, Xianming
Li, Changkang
Li, Baoming
Chen, Ruoyun
Kang, Jie
A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title_full A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title_fullStr A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title_full_unstemmed A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title_short A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
title_sort new nortriterpenoid, a sesquiterpene and hepatoprotective lignans isolated from the fruit of schisandra chinensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150265/
https://www.ncbi.nlm.nih.gov/pubmed/29125562
http://dx.doi.org/10.3390/molecules22111931
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