Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein

O(6)-Alkylguanine-DNA alkyltransferases (AGTs) are proteins responsible for the removal of mutagenic alkyl adducts at the O(6)-atom of guanine and O(4)-atom of thymine. In the current study we set out to understand the role of the Ser134 residue in the Escherichia coli AGT variant OGT on substrate d...

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Detalles Bibliográficos
Autores principales: Schoonhoven, Nadia M., O’Flaherty, Derek K., McManus, Francis P., Sacre, Lauralicia, Noronha, Anne M., Kornblatt, M. Judith, Wilds, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150290/
https://www.ncbi.nlm.nih.gov/pubmed/29137116
http://dx.doi.org/10.3390/molecules22111948

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