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Neuraminidase Inhibitory Activity and Constituent Characterization of Fagopyrum dibotrys

This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identifi...

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Detalles Bibliográficos
Autores principales: Zhang, Xiang, Cao, Yu, Li, Jinhua, Liu, Ailin, Liu, Haibo, Huang, Linfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150301/
https://www.ncbi.nlm.nih.gov/pubmed/29156573
http://dx.doi.org/10.3390/molecules22111998
Descripción
Sumario:This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds’ anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F. dibotrys. Docking studies and NA activity assay revealed the remarkable NA inhibitory activity of eight components in EA extract, especially rutin, hesperidin, procyanidin B(2), and quercitrin. Therefore, F. dibotrys could be used to develop anti-influenza drugs.