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Synthesis and Structure–Activity Relationships of 4-Morpholino-7,8-Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold

Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is abnormally active in the growth and proliferation of cancer cells. The inhibition of PI3K kinase can effectively block the conduction of signaling pathways and is an ideal target for dru...

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Detalles Bibliográficos
Autores principales:	Wang, Qinqin, Li, Xiaojing, Sun, Chengyu, Zhang, Binliang, Zheng, Pengwu, Zhu, Wufu, Xu, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150310/ https://www.ncbi.nlm.nih.gov/pubmed/29088090 http://dx.doi.org/10.3390/molecules22111870

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