Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence

In this report, we investigate the efficiency and selectivity of a Zn(2+)-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt) and sequences in the bulge formed upon bind...

Descripción completa

Detalles Bibliográficos
Autores principales: Murtola, Merita, Ghidini, Alice, Virta, Pasi, Strömberg, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150328/
https://www.ncbi.nlm.nih.gov/pubmed/29109368
http://dx.doi.org/10.3390/molecules22111856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150328/
https://www.ncbi.nlm.nih.gov/pubmed/29109368
http://dx.doi.org/10.3390/molecules22111856

Ejemplares similares