The Novel Triazolonaphthalimide Derivative LSS-11 Synergizes the Anti-Proliferative Effect of Paclitaxel via STAT3-Dependent MDR1 and MRP1 Downregulation in Chemoresistant Lung Cancer Cells

Multidrug resistance (MDR) is a major cause of the inefficacy and poor response to paclitaxel-based chemotherapy. The combination of conventional cytotoxic drugs has been a plausible strategy for overcoming paclitaxel resistance. Herein, we investigated the cytotoxic effects and underlying mechanism...

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Detalles Bibliográficos
Autores principales: Ji, Liyan, Liu, Xi, Zhang, Shuwei, Tang, Shunan, Yang, Simin, Li, Shasha, Qi, Xiaoxiao, Yu, Siwang, Lu, Linlin, Meng, Xiangbao, Liu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150343/
https://www.ncbi.nlm.nih.gov/pubmed/29072615
http://dx.doi.org/10.3390/molecules22111822

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