Halogen–Metal Exchange on Bromoheterocyclics with Substituents Containing an Acidic Proton via Formation of a Magnesium Intermediate

A selective and practical bromine–metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. Our protocol of using a combination of i-PrMgCl and n-BuLi has not only solved the problem...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Qingqiang, Shang, Suqin, Wang, Huajun, Shi, Guoqiang, Li, Zhiyao, Yuan, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150384/
https://www.ncbi.nlm.nih.gov/pubmed/29137130
http://dx.doi.org/10.3390/molecules22111952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150384/
https://www.ncbi.nlm.nih.gov/pubmed/29137130
http://dx.doi.org/10.3390/molecules22111952

Ejemplares similares