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Halogen–Metal Exchange on Bromoheterocyclics with Substituents Containing an Acidic Proton via Formation of a Magnesium Intermediate

A selective and practical bromine–metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. Our protocol of using a combination of i-PrMgCl and n-BuLi has not only solved the problem...

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Detalles Bibliográficos
Autores principales:	Tian, Qingqiang, Shang, Suqin, Wang, Huajun, Shi, Guoqiang, Li, Zhiyao, Yuan, Jianyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150384/ https://www.ncbi.nlm.nih.gov/pubmed/29137130 http://dx.doi.org/10.3390/molecules22111952

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