Cargando…
Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort
OBJECTIVE: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabe...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150428/ https://www.ncbi.nlm.nih.gov/pubmed/30104298 http://dx.doi.org/10.2337/dc18-0255 |
_version_ | 1783356989876731904 |
---|---|
author | Wessells, Hunter Braffett, Barbara H. Holt, Sarah K. Jacobson, Alan M. Kusek, John W. Cowie, Catherine Dunn, Rodney L. Sarma, Aruna V. |
author_facet | Wessells, Hunter Braffett, Barbara H. Holt, Sarah K. Jacobson, Alan M. Kusek, John W. Cowie, Catherine Dunn, Rodney L. Sarma, Aruna V. |
author_sort | Wessells, Hunter |
collection | PubMed |
description | OBJECTIVE: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission. RESEARCH DESIGN AND METHODS: This ancillary longitudinal study among participants in the Diabetes Control and Complications Trial (DCCT) and observational follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) (652 women and 713 men) was conducted in 2003 and 2010/2011. Urinary incontinence (UI), lower urinary tract symptoms, urinary tract infection, female sexual dysfunction, erectile dysfunction, low male sexual desire, and orgasmic dysfunction were measured with validated instruments. Logistic regression determined association of complications with demographics and clinical characteristics. RESULTS: Of sexually active women completing the 2010/2011 survey, 35% reported no complications, 39% had one, 19% two, 5% three, and 2% four. In men, 31% had no complications, 36% had one, 22% two, 9% three, and 3% four. Sexual dysfunction was most prevalent (42% women and 45% men) followed by UI in women (31%) and low sexual desire in men (40%). Urological complications were associated with age, BMI, and HbA(1c). Remission rates ranged from 4 to 12% over the 7-year interval between surveys. CONCLUSIONS: Urological complications are prevalent and frequently co-occur in persons with type 1 diabetes. Remission rates in a minority subset indicate a rationale for future studies to mitigate the onset or impact of urological complications of diabetes. |
format | Online Article Text |
id | pubmed-6150428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-61504282019-10-01 Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort Wessells, Hunter Braffett, Barbara H. Holt, Sarah K. Jacobson, Alan M. Kusek, John W. Cowie, Catherine Dunn, Rodney L. Sarma, Aruna V. Diabetes Care Pathophysiology/Complications OBJECTIVE: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission. RESEARCH DESIGN AND METHODS: This ancillary longitudinal study among participants in the Diabetes Control and Complications Trial (DCCT) and observational follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) (652 women and 713 men) was conducted in 2003 and 2010/2011. Urinary incontinence (UI), lower urinary tract symptoms, urinary tract infection, female sexual dysfunction, erectile dysfunction, low male sexual desire, and orgasmic dysfunction were measured with validated instruments. Logistic regression determined association of complications with demographics and clinical characteristics. RESULTS: Of sexually active women completing the 2010/2011 survey, 35% reported no complications, 39% had one, 19% two, 5% three, and 2% four. In men, 31% had no complications, 36% had one, 22% two, 9% three, and 3% four. Sexual dysfunction was most prevalent (42% women and 45% men) followed by UI in women (31%) and low sexual desire in men (40%). Urological complications were associated with age, BMI, and HbA(1c). Remission rates ranged from 4 to 12% over the 7-year interval between surveys. CONCLUSIONS: Urological complications are prevalent and frequently co-occur in persons with type 1 diabetes. Remission rates in a minority subset indicate a rationale for future studies to mitigate the onset or impact of urological complications of diabetes. American Diabetes Association 2018-10 2018-08-13 /pmc/articles/PMC6150428/ /pubmed/30104298 http://dx.doi.org/10.2337/dc18-0255 Text en © 2018 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license. |
spellingShingle | Pathophysiology/Complications Wessells, Hunter Braffett, Barbara H. Holt, Sarah K. Jacobson, Alan M. Kusek, John W. Cowie, Catherine Dunn, Rodney L. Sarma, Aruna V. Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title | Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title_full | Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title_fullStr | Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title_full_unstemmed | Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title_short | Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort |
title_sort | burden of urological complications in men and women with long-standing type 1 diabetes in the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort |
topic | Pathophysiology/Complications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150428/ https://www.ncbi.nlm.nih.gov/pubmed/30104298 http://dx.doi.org/10.2337/dc18-0255 |
work_keys_str_mv | AT wessellshunter burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT braffettbarbarah burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT holtsarahk burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT jacobsonalanm burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT kusekjohnw burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT cowiecatherine burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT dunnrodneyl burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT sarmaarunav burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort AT burdenofurologicalcomplicationsinmenandwomenwithlongstandingtype1diabetesinthediabetescontrolandcomplicationstrialepidemiologyofdiabetesinterventionsandcomplicationscohort |