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Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis

BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studie...

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Autores principales: Xu, Mingzhu, Xu, Jialiang, Yang, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150547/
https://www.ncbi.nlm.nih.gov/pubmed/28377538
http://dx.doi.org/10.5144/0256-4947.2017.99
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author Xu, Mingzhu
Xu, Jialiang
Yang, Xiangjun
author_facet Xu, Mingzhu
Xu, Jialiang
Yang, Xiangjun
author_sort Xu, Mingzhu
collection PubMed
description BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studies. DESIGN: Fixed and random effects models were used to calculate risk estimates in a meta-analysis. Potential publication bias was calculated using a funnel plot, Begg’s rank correlation test, and Egger’s linear regression test. SEARCH STRATEGY: We searched the PubMed and Embase databases for studies that examined the relationship between asthma and CVD or all-cause mortality. SELECTION CRITERIA: Prospective and retrospective cohort studies. RESULTS: Ten studies containing 406 426 participants were included. The summary relative risk (95% confidence interval, CI) for patients with asthma was 1.33 (95% CI: 1.15–1.53), for CVD in women, it was 1.55 (95% CI: 1.20–2.00), for CVD in men it was 1.20 (95% CI: 0.92–1.56), and for all-cause mortality in both genders it was 1.36 (95% CI: 1.01–1.83). These findings remained consistent after sensitivity analysis. CONCLUSION: The results indicate that asthma was associated with an increased risk of CVD and all-cause mortality.
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spelling pubmed-61505472018-09-25 Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis Xu, Mingzhu Xu, Jialiang Yang, Xiangjun Ann Saudi Med Review BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studies. DESIGN: Fixed and random effects models were used to calculate risk estimates in a meta-analysis. Potential publication bias was calculated using a funnel plot, Begg’s rank correlation test, and Egger’s linear regression test. SEARCH STRATEGY: We searched the PubMed and Embase databases for studies that examined the relationship between asthma and CVD or all-cause mortality. SELECTION CRITERIA: Prospective and retrospective cohort studies. RESULTS: Ten studies containing 406 426 participants were included. The summary relative risk (95% confidence interval, CI) for patients with asthma was 1.33 (95% CI: 1.15–1.53), for CVD in women, it was 1.55 (95% CI: 1.20–2.00), for CVD in men it was 1.20 (95% CI: 0.92–1.56), and for all-cause mortality in both genders it was 1.36 (95% CI: 1.01–1.83). These findings remained consistent after sensitivity analysis. CONCLUSION: The results indicate that asthma was associated with an increased risk of CVD and all-cause mortality. King Faisal Specialist Hospital and Research Centre 2017 /pmc/articles/PMC6150547/ /pubmed/28377538 http://dx.doi.org/10.5144/0256-4947.2017.99 Text en © 2017 Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review
Xu, Mingzhu
Xu, Jialiang
Yang, Xiangjun
Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title_full Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title_fullStr Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title_full_unstemmed Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title_short Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
title_sort asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150547/
https://www.ncbi.nlm.nih.gov/pubmed/28377538
http://dx.doi.org/10.5144/0256-4947.2017.99
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