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Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis
BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studie...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
King Faisal Specialist Hospital and Research Centre
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150547/ https://www.ncbi.nlm.nih.gov/pubmed/28377538 http://dx.doi.org/10.5144/0256-4947.2017.99 |
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author | Xu, Mingzhu Xu, Jialiang Yang, Xiangjun |
author_facet | Xu, Mingzhu Xu, Jialiang Yang, Xiangjun |
author_sort | Xu, Mingzhu |
collection | PubMed |
description | BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studies. DESIGN: Fixed and random effects models were used to calculate risk estimates in a meta-analysis. Potential publication bias was calculated using a funnel plot, Begg’s rank correlation test, and Egger’s linear regression test. SEARCH STRATEGY: We searched the PubMed and Embase databases for studies that examined the relationship between asthma and CVD or all-cause mortality. SELECTION CRITERIA: Prospective and retrospective cohort studies. RESULTS: Ten studies containing 406 426 participants were included. The summary relative risk (95% confidence interval, CI) for patients with asthma was 1.33 (95% CI: 1.15–1.53), for CVD in women, it was 1.55 (95% CI: 1.20–2.00), for CVD in men it was 1.20 (95% CI: 0.92–1.56), and for all-cause mortality in both genders it was 1.36 (95% CI: 1.01–1.83). These findings remained consistent after sensitivity analysis. CONCLUSION: The results indicate that asthma was associated with an increased risk of CVD and all-cause mortality. |
format | Online Article Text |
id | pubmed-6150547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | King Faisal Specialist Hospital and Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-61505472018-09-25 Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis Xu, Mingzhu Xu, Jialiang Yang, Xiangjun Ann Saudi Med Review BACKGROUND: Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. OBJECTIVES: To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studies. DESIGN: Fixed and random effects models were used to calculate risk estimates in a meta-analysis. Potential publication bias was calculated using a funnel plot, Begg’s rank correlation test, and Egger’s linear regression test. SEARCH STRATEGY: We searched the PubMed and Embase databases for studies that examined the relationship between asthma and CVD or all-cause mortality. SELECTION CRITERIA: Prospective and retrospective cohort studies. RESULTS: Ten studies containing 406 426 participants were included. The summary relative risk (95% confidence interval, CI) for patients with asthma was 1.33 (95% CI: 1.15–1.53), for CVD in women, it was 1.55 (95% CI: 1.20–2.00), for CVD in men it was 1.20 (95% CI: 0.92–1.56), and for all-cause mortality in both genders it was 1.36 (95% CI: 1.01–1.83). These findings remained consistent after sensitivity analysis. CONCLUSION: The results indicate that asthma was associated with an increased risk of CVD and all-cause mortality. King Faisal Specialist Hospital and Research Centre 2017 /pmc/articles/PMC6150547/ /pubmed/28377538 http://dx.doi.org/10.5144/0256-4947.2017.99 Text en © 2017 Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Xu, Mingzhu Xu, Jialiang Yang, Xiangjun Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title | Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title_full | Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title_fullStr | Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title_full_unstemmed | Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title_short | Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
title_sort | asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150547/ https://www.ncbi.nlm.nih.gov/pubmed/28377538 http://dx.doi.org/10.5144/0256-4947.2017.99 |
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