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Neurohormonal changes in medical students during academic stress

BACKGROUND: Academic stress is a good model of psychological stress in humans and is thus useful for studying psychoneurohormonal changes. The aim of the current study was to examine the effect of academic examination stress on activation of the hypothalamus-autonomic nervous system (HANS) and the h...

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Autor principal: Al-Ayadhi, Laila Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150563/
https://www.ncbi.nlm.nih.gov/pubmed/15822492
http://dx.doi.org/10.5144/0256-4947.2005.36
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author Al-Ayadhi, Laila Y.
author_facet Al-Ayadhi, Laila Y.
author_sort Al-Ayadhi, Laila Y.
collection PubMed
description BACKGROUND: Academic stress is a good model of psychological stress in humans and is thus useful for studying psychoneurohormonal changes. The aim of the current study was to examine the effect of academic examination stress on activation of the hypothalamus-autonomic nervous system (HANS) and the hypothalamic-pituitary-adrenocortical (HPA) axis, through the measurements of changes in neuro-hormones during final exams as compared to the pre-exam baseline. MATERIALS AND METHODS: Forty-eight first- and second-year female medical students participated. Plasma leptin, neuropeptide Y (NPY), nitrite, nitrate, andrenomedullin, cortisol and adrenocorticotropic hormone (ACTH) were measured at baseline and during final examinations. RESULTS: Plasma levels of cortisol, ACTH, NPY, adrenomedullin, nitrite and nitrate increased during times of academic stress as compared to baseline levels. However, only plasma leptin level was decreased during the academic stress as compared to baseline, probably through a negative feedback mechanism resulting from sympathetic stimulation. The results indicate that both the HANS and HPA are involved in this type of stress and both are activated at the same time. CONCLUSION: : Academic stress induced significant neurohormonal changes. Leptin, NPY, nitrite, nitrate, adrenomedullin, cortisol and ACTH can be considered part of a complex mosaic model of the neuroendocrine system during academic stress.
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spelling pubmed-61505632018-09-25 Neurohormonal changes in medical students during academic stress Al-Ayadhi, Laila Y. Ann Saudi Med Original Article BACKGROUND: Academic stress is a good model of psychological stress in humans and is thus useful for studying psychoneurohormonal changes. The aim of the current study was to examine the effect of academic examination stress on activation of the hypothalamus-autonomic nervous system (HANS) and the hypothalamic-pituitary-adrenocortical (HPA) axis, through the measurements of changes in neuro-hormones during final exams as compared to the pre-exam baseline. MATERIALS AND METHODS: Forty-eight first- and second-year female medical students participated. Plasma leptin, neuropeptide Y (NPY), nitrite, nitrate, andrenomedullin, cortisol and adrenocorticotropic hormone (ACTH) were measured at baseline and during final examinations. RESULTS: Plasma levels of cortisol, ACTH, NPY, adrenomedullin, nitrite and nitrate increased during times of academic stress as compared to baseline levels. However, only plasma leptin level was decreased during the academic stress as compared to baseline, probably through a negative feedback mechanism resulting from sympathetic stimulation. The results indicate that both the HANS and HPA are involved in this type of stress and both are activated at the same time. CONCLUSION: : Academic stress induced significant neurohormonal changes. Leptin, NPY, nitrite, nitrate, adrenomedullin, cortisol and ACTH can be considered part of a complex mosaic model of the neuroendocrine system during academic stress. King Faisal Specialist Hospital and Research Centre 2005 /pmc/articles/PMC6150563/ /pubmed/15822492 http://dx.doi.org/10.5144/0256-4947.2005.36 Text en Copyright © 2005, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Al-Ayadhi, Laila Y.
Neurohormonal changes in medical students during academic stress
title Neurohormonal changes in medical students during academic stress
title_full Neurohormonal changes in medical students during academic stress
title_fullStr Neurohormonal changes in medical students during academic stress
title_full_unstemmed Neurohormonal changes in medical students during academic stress
title_short Neurohormonal changes in medical students during academic stress
title_sort neurohormonal changes in medical students during academic stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150563/
https://www.ncbi.nlm.nih.gov/pubmed/15822492
http://dx.doi.org/10.5144/0256-4947.2005.36
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