Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

The linear pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) can be considered a class property with values that are similar to endogenous IgG. Knowledge of these parameters across species could be used to avoid unnecessary in vivo PK studies and to enable early PK predictions and ph...

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Detalles Bibliográficos
Autores principales: Betts, Alison, Keunecke, Anne, van Steeg, Tamara J., van der Graaf, Piet H., Avery, Lindsay B., Jones, Hannah, Berkhout, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150614/
https://www.ncbi.nlm.nih.gov/pubmed/29634430
http://dx.doi.org/10.1080/19420862.2018.1462429

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