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The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy, some IgG1 antibodies rely on the Fc-mediated immune effector function, antibody-dependent cellular cytotoxicity (ADCC),...

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Detalles Bibliográficos
Autores principales:	Pereira, Natasha A., Chan, Kah Fai, Lin, Pao Chun, Song, Zhiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150623/ https://www.ncbi.nlm.nih.gov/pubmed/29733746 http://dx.doi.org/10.1080/19420862.2018.1466767

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