An end in sight? Xrn2 and transcriptional termination by RNA polymerase II

Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcri...

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Detalles Bibliográficos
Autores principales: Eaton, Joshua D., West, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150625/
https://www.ncbi.nlm.nih.gov/pubmed/30035655
http://dx.doi.org/10.1080/21541264.2018.1498708
Descripción
Sumario:Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcriptional termination by RNA polymerase II in human cells.

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