An end in sight? Xrn2 and transcriptional termination by RNA polymerase II

Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcri...

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Detalles Bibliográficos
Autores principales: Eaton, Joshua D., West, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150625/
https://www.ncbi.nlm.nih.gov/pubmed/30035655
http://dx.doi.org/10.1080/21541264.2018.1498708
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author Eaton, Joshua D.
West, Steven
author_facet Eaton, Joshua D.
West, Steven
author_sort Eaton, Joshua D.
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description Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcriptional termination by RNA polymerase II in human cells.
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spelling pubmed-61506252018-09-24 An end in sight? Xrn2 and transcriptional termination by RNA polymerase II Eaton, Joshua D. West, Steven Transcription Point-of-View Every transcription cycle ends in termination when RNA polymerase dissociates from the DNA. Although conceptually simple, the mechanism has proven somewhat elusive in eukaryotic systems. Gene-editing and high resolution polymerase mapping now offer clarification of important steps preceding transcriptional termination by RNA polymerase II in human cells. Taylor & Francis 2018-08-02 /pmc/articles/PMC6150625/ /pubmed/30035655 http://dx.doi.org/10.1080/21541264.2018.1498708 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Point-of-View
Eaton, Joshua D.
West, Steven
An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title_full An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title_fullStr An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title_full_unstemmed An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title_short An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
title_sort end in sight? xrn2 and transcriptional termination by rna polymerase ii
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150625/
https://www.ncbi.nlm.nih.gov/pubmed/30035655
http://dx.doi.org/10.1080/21541264.2018.1498708
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