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Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients

Type 2 diabetes mellitus (T2DM) has high morbidity and results in increased risk of mortality mainly due to cardiovascular diseases. Different factors have been found to be responsible for the increased prevalence of coronary artery disease (CAD) in T2DM. One of these factors includes raised serum l...

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Autores principales: Peela, Jagannadha R, Latiwesh, Omar B, Elshaari, Farag, Hussain, Azhar, Tabrez, Elsa, Viglianco, Emily, Edwards, Ajené, Ali, Farwa, Rawal, Avinash K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150746/
https://www.ncbi.nlm.nih.gov/pubmed/30254819
http://dx.doi.org/10.7759/cureus.3030
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author Peela, Jagannadha R
Latiwesh, Omar B
Elshaari, Farag
Hussain, Azhar
Tabrez, Elsa
Viglianco, Emily
Edwards, Ajené
Ali, Farwa
Rawal, Avinash K
author_facet Peela, Jagannadha R
Latiwesh, Omar B
Elshaari, Farag
Hussain, Azhar
Tabrez, Elsa
Viglianco, Emily
Edwards, Ajené
Ali, Farwa
Rawal, Avinash K
author_sort Peela, Jagannadha R
collection PubMed
description Type 2 diabetes mellitus (T2DM) has high morbidity and results in increased risk of mortality mainly due to cardiovascular diseases. Different factors have been found to be responsible for the increased prevalence of coronary artery disease (CAD) in T2DM. One of these factors includes raised serum levels of lipoprotein(a) (Lp(a)). The present study was designed to evaluate the association of Lp(a) levels with T2DM in Libyan patients and find the degree of association between Lp(a), glycemic control, insulin, and lipid profile. The study included 100 T2DM patients, recruited from the Benghazi Center for Diagnosis and Treatment of Diabetes, and 30 apparently healthy age and sex-matched individuals, to serve as controls. All participants completed a questionnaire to obtain clinical information and medical history. Blood samples were collected and analyzed for Lp(a), fasting blood glucose (FBS), HbA1c, insulin, total cholesterol (TC), triglycerides (TAG), low-density lipoprotein c (LDL-c), and high-density lipoprotein c (HDL-c). The results from the comparison between the control and experimental groups showed that Lp(a) was significantly higher in diabetic patients. It showed the positive correlation with TC and LDL-c. On the contrary, it showed no significant correlations with glycemic control parameters nor insulin, TAG, HDL-c, body mass index (BMI), and blood pressor (BP). Cardiovascular disease (CVD) risk in type 2 diabetic patients could be dependent on risk factors other than LDL-c, which may not be an independent risk factor for the development and progression of atherogenesis in T2DM. Lp(a) may be a new metabolic syndrome risk factor, and it may be useful as a cardiovascular risk biomarker in future clinical practice.
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spelling pubmed-61507462018-09-25 Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients Peela, Jagannadha R Latiwesh, Omar B Elshaari, Farag Hussain, Azhar Tabrez, Elsa Viglianco, Emily Edwards, Ajené Ali, Farwa Rawal, Avinash K Cureus Cardiology Type 2 diabetes mellitus (T2DM) has high morbidity and results in increased risk of mortality mainly due to cardiovascular diseases. Different factors have been found to be responsible for the increased prevalence of coronary artery disease (CAD) in T2DM. One of these factors includes raised serum levels of lipoprotein(a) (Lp(a)). The present study was designed to evaluate the association of Lp(a) levels with T2DM in Libyan patients and find the degree of association between Lp(a), glycemic control, insulin, and lipid profile. The study included 100 T2DM patients, recruited from the Benghazi Center for Diagnosis and Treatment of Diabetes, and 30 apparently healthy age and sex-matched individuals, to serve as controls. All participants completed a questionnaire to obtain clinical information and medical history. Blood samples were collected and analyzed for Lp(a), fasting blood glucose (FBS), HbA1c, insulin, total cholesterol (TC), triglycerides (TAG), low-density lipoprotein c (LDL-c), and high-density lipoprotein c (HDL-c). The results from the comparison between the control and experimental groups showed that Lp(a) was significantly higher in diabetic patients. It showed the positive correlation with TC and LDL-c. On the contrary, it showed no significant correlations with glycemic control parameters nor insulin, TAG, HDL-c, body mass index (BMI), and blood pressor (BP). Cardiovascular disease (CVD) risk in type 2 diabetic patients could be dependent on risk factors other than LDL-c, which may not be an independent risk factor for the development and progression of atherogenesis in T2DM. Lp(a) may be a new metabolic syndrome risk factor, and it may be useful as a cardiovascular risk biomarker in future clinical practice. Cureus 2018-07-23 /pmc/articles/PMC6150746/ /pubmed/30254819 http://dx.doi.org/10.7759/cureus.3030 Text en Copyright © 2018, Peela et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Peela, Jagannadha R
Latiwesh, Omar B
Elshaari, Farag
Hussain, Azhar
Tabrez, Elsa
Viglianco, Emily
Edwards, Ajené
Ali, Farwa
Rawal, Avinash K
Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title_full Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title_fullStr Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title_full_unstemmed Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title_short Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients
title_sort investigating the atherogenic risk of lipoprotein(a) in type 2 diabetic patients
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150746/
https://www.ncbi.nlm.nih.gov/pubmed/30254819
http://dx.doi.org/10.7759/cureus.3030
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