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Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review
Adult-onset Still’s disease (AOSD) is a rare diagnosis. In small percentage of cases, AOSD is associated with other autoimmune diseases including schizophrenia. Despite the lack of sufficient studies, both conditions may share similar autoimmune pathogenic pathways. Herein we describe a 36-year-old...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150749/ https://www.ncbi.nlm.nih.gov/pubmed/30254808 http://dx.doi.org/10.7759/cureus.3019 |
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author | Golchin, Nasim Sharifzadeh, Mohaddeseh Fransawy Alkomos, Mina Sachmechi, Issac |
author_facet | Golchin, Nasim Sharifzadeh, Mohaddeseh Fransawy Alkomos, Mina Sachmechi, Issac |
author_sort | Golchin, Nasim |
collection | PubMed |
description | Adult-onset Still’s disease (AOSD) is a rare diagnosis. In small percentage of cases, AOSD is associated with other autoimmune diseases including schizophrenia. Despite the lack of sufficient studies, both conditions may share similar autoimmune pathogenic pathways. Herein we describe a 36-year-old woman with the past medical history of schizophrenia who presented with spiking fevers, arthralgia, evanescent rash and pleural chest pain. She reported developing these symptoms a while after poor compliance with her antipsychotic medication. On admission, physical examination was remarkable for high-grade fever, maculopapular rash, oligo arthralgia, hepatomegaly and lymphadenopathy. Laboratory investigation revealed leukocytosis with neutrophilia and markedly elevated ferritin. The patient met four out of four major, and three out of five minor Yamaguchi criteria for AOSD. The patient started on therapy with corticosteroid. Soon after, her symptoms resolved and most of her biochemical markers went back to normal. We review the literature on co-existence of AOSD with other autoimmune diseases, we also discuss that there may be a correlation between ceasing antipsychotic medication (with known immunomodulatory effect) in a schizophrenic patient and triggering an auto-inflammatory process such as AOSD in a susceptible host. In addition, we discussed the possible similar autoimmune pathway of schizophrenia to pathogenesis of AOSD. |
format | Online Article Text |
id | pubmed-6150749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-61507492018-09-25 Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review Golchin, Nasim Sharifzadeh, Mohaddeseh Fransawy Alkomos, Mina Sachmechi, Issac Cureus Endocrinology/Diabetes/Metabolism Adult-onset Still’s disease (AOSD) is a rare diagnosis. In small percentage of cases, AOSD is associated with other autoimmune diseases including schizophrenia. Despite the lack of sufficient studies, both conditions may share similar autoimmune pathogenic pathways. Herein we describe a 36-year-old woman with the past medical history of schizophrenia who presented with spiking fevers, arthralgia, evanescent rash and pleural chest pain. She reported developing these symptoms a while after poor compliance with her antipsychotic medication. On admission, physical examination was remarkable for high-grade fever, maculopapular rash, oligo arthralgia, hepatomegaly and lymphadenopathy. Laboratory investigation revealed leukocytosis with neutrophilia and markedly elevated ferritin. The patient met four out of four major, and three out of five minor Yamaguchi criteria for AOSD. The patient started on therapy with corticosteroid. Soon after, her symptoms resolved and most of her biochemical markers went back to normal. We review the literature on co-existence of AOSD with other autoimmune diseases, we also discuss that there may be a correlation between ceasing antipsychotic medication (with known immunomodulatory effect) in a schizophrenic patient and triggering an auto-inflammatory process such as AOSD in a susceptible host. In addition, we discussed the possible similar autoimmune pathway of schizophrenia to pathogenesis of AOSD. Cureus 2018-07-21 /pmc/articles/PMC6150749/ /pubmed/30254808 http://dx.doi.org/10.7759/cureus.3019 Text en Copyright © 2018, Golchin et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Golchin, Nasim Sharifzadeh, Mohaddeseh Fransawy Alkomos, Mina Sachmechi, Issac Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title | Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title_full | Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title_fullStr | Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title_full_unstemmed | Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title_short | Adult-onset Still’s Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review |
title_sort | adult-onset still’s disease in a female patient with schizophrenia: a case report and literature review |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150749/ https://www.ncbi.nlm.nih.gov/pubmed/30254808 http://dx.doi.org/10.7759/cureus.3019 |
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