Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion

Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research. Helper T lymphocytes (Th cells) and regulatory T lymphocytes (Treg cells) are central in human immune regulation and play a complex rol...

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Autores principales: Zhao, Xiaoxuan, Jiang, Yuepeng, Wang, Lin, Li, Zhihao, Li, Qiang, Feng, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150770/
https://www.ncbi.nlm.nih.gov/pubmed/30258242
http://dx.doi.org/10.1055/a-0634-1813
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author Zhao, Xiaoxuan
Jiang, Yuepeng
Wang, Lin
Li, Zhihao
Li, Qiang
Feng, Xiaoling
author_facet Zhao, Xiaoxuan
Jiang, Yuepeng
Wang, Lin
Li, Zhihao
Li, Qiang
Feng, Xiaoling
author_sort Zhao, Xiaoxuan
collection PubMed
description Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research. Helper T lymphocytes (Th cells) and regulatory T lymphocytes (Treg cells) are central in human immune regulation and play a complex role in pregnancy. Natural killer cells (NK cells) exist in the endometrium and cooperate with T lymphocytes to create immune tolerance at the maternal-fetal interface, which is essential for successful pregnancy. This review has analyzed studies on Th17 cell, Treg cell and NK cell dysfunction and cellular imbalances which may contribute to unexplained recurrent spontaneous abortion to suggest a possible direction for future immunotherapies.
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spelling pubmed-61507702018-09-24 Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion Zhao, Xiaoxuan Jiang, Yuepeng Wang, Lin Li, Zhihao Li, Qiang Feng, Xiaoling Geburtshilfe Frauenheilkd Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research. Helper T lymphocytes (Th cells) and regulatory T lymphocytes (Treg cells) are central in human immune regulation and play a complex role in pregnancy. Natural killer cells (NK cells) exist in the endometrium and cooperate with T lymphocytes to create immune tolerance at the maternal-fetal interface, which is essential for successful pregnancy. This review has analyzed studies on Th17 cell, Treg cell and NK cell dysfunction and cellular imbalances which may contribute to unexplained recurrent spontaneous abortion to suggest a possible direction for future immunotherapies. Georg Thieme Verlag KG 2018-07 2018-07-25 /pmc/articles/PMC6150770/ /pubmed/30258242 http://dx.doi.org/10.1055/a-0634-1813 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Zhao, Xiaoxuan
Jiang, Yuepeng
Wang, Lin
Li, Zhihao
Li, Qiang
Feng, Xiaoling
Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title_full Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title_fullStr Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title_full_unstemmed Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title_short Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion
title_sort advances in understanding the immune imbalance between t-lymphocyte subsets and nk cells in recurrent spontaneous abortion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150770/
https://www.ncbi.nlm.nih.gov/pubmed/30258242
http://dx.doi.org/10.1055/a-0634-1813
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