Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([(18)F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

BACKGROUND: Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)-N-(4-methoxyphenyl)hydrazine-carbothioamide...

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Detalles Bibliográficos
Autores principales: Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Huisman, Marc, Schuit, Robert C., Molthoff, Carla F. M., Voskuyl, Rob A., de Lange, Elizabeth C., Lammertsma, Adriaan A., Windhorst, Albert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150866/
https://www.ncbi.nlm.nih.gov/pubmed/30294663
http://dx.doi.org/10.1186/s41181-018-0046-z

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