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The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

BACKGROUND: The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is overexpressed in a variety of human neoplasms, its expression and its role in thyroid cancer is currently unknown. Anaplastic thyroid carcinoma (ATC) is a highly a...

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Detalles Bibliográficos
Autores principales:	Häfliger, Pascal, Graff, Julien, Rubin, Matthias, Stooss, Amandine, Dettmer, Matthias S., Altmann, Karl-Heinz, Gertsch, Jürg, Charles, Roch-Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150977/ https://www.ncbi.nlm.nih.gov/pubmed/30241549 http://dx.doi.org/10.1186/s13046-018-0907-z

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