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BayesCCE: a Bayesian framework for estimating cell-type composition from DNA methylation without the need for methylation reference
We introduce a Bayesian semi-supervised method for estimating cell counts from DNA methylation by leveraging an easily obtainable prior knowledge on the cell-type composition distribution of the studied tissue. We show mathematically and empirically that alternative methods which attempt to infer ce...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151042/ https://www.ncbi.nlm.nih.gov/pubmed/30241486 http://dx.doi.org/10.1186/s13059-018-1513-2 |