Obesity Increases the Duration of Influenza A Virus Shedding in Adults

Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicara...

Descripción completa

Detalles Bibliográficos
Autores principales: Maier, Hannah E, Lopez, Roger, Sanchez, Nery, Ng, Sophia, Gresh, Lionel, Ojeda, Sergio, Burger-Calderon, Raquel, Kuan, Guillermina, Harris, Eva, Balmaseda, Angel, Gordon, Aubree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151083/
https://www.ncbi.nlm.nih.gov/pubmed/30085119
http://dx.doi.org/10.1093/infdis/jiy370
_version_ 1783357100257181696
author Maier, Hannah E
Lopez, Roger
Sanchez, Nery
Ng, Sophia
Gresh, Lionel
Ojeda, Sergio
Burger-Calderon, Raquel
Kuan, Guillermina
Harris, Eva
Balmaseda, Angel
Gordon, Aubree
author_facet Maier, Hannah E
Lopez, Roger
Sanchez, Nery
Ng, Sophia
Gresh, Lionel
Ojeda, Sergio
Burger-Calderon, Raquel
Kuan, Guillermina
Harris, Eva
Balmaseda, Angel
Gordon, Aubree
author_sort Maier, Hannah E
collection PubMed
description Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015–2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06–1.89); no association was observed with influenza B virus shedding duration. Even among paucisymptomatic and asymptomatic adults, obesity increased the influenza A shedding duration by 104% (adjusted ETR, 2.04; 95% CI, 1.35–3.09). These findings suggest that obesity may play an important role in influenza transmission.
format Online
Article
Text
id pubmed-6151083
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-61510832018-09-26 Obesity Increases the Duration of Influenza A Virus Shedding in Adults Maier, Hannah E Lopez, Roger Sanchez, Nery Ng, Sophia Gresh, Lionel Ojeda, Sergio Burger-Calderon, Raquel Kuan, Guillermina Harris, Eva Balmaseda, Angel Gordon, Aubree J Infect Dis Major Articles and Brief Reports Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015–2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06–1.89); no association was observed with influenza B virus shedding duration. Even among paucisymptomatic and asymptomatic adults, obesity increased the influenza A shedding duration by 104% (adjusted ETR, 2.04; 95% CI, 1.35–3.09). These findings suggest that obesity may play an important role in influenza transmission. Oxford University Press 2018-11-01 2018-08-02 /pmc/articles/PMC6151083/ /pubmed/30085119 http://dx.doi.org/10.1093/infdis/jiy370 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Maier, Hannah E
Lopez, Roger
Sanchez, Nery
Ng, Sophia
Gresh, Lionel
Ojeda, Sergio
Burger-Calderon, Raquel
Kuan, Guillermina
Harris, Eva
Balmaseda, Angel
Gordon, Aubree
Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title_full Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title_fullStr Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title_full_unstemmed Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title_short Obesity Increases the Duration of Influenza A Virus Shedding in Adults
title_sort obesity increases the duration of influenza a virus shedding in adults
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151083/
https://www.ncbi.nlm.nih.gov/pubmed/30085119
http://dx.doi.org/10.1093/infdis/jiy370
work_keys_str_mv AT maierhannahe obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT lopezroger obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT sancheznery obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT ngsophia obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT greshlionel obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT ojedasergio obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT burgercalderonraquel obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT kuanguillermina obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT harriseva obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT balmasedaangel obesityincreasesthedurationofinfluenzaavirussheddinginadults
AT gordonaubree obesityincreasesthedurationofinfluenzaavirussheddinginadults

Ejemplares similares