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Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice

INTRODUCTION: The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management of anxiety, psychosis, and epilepsy. AIM OF THE STUDY: We therefore aimed at evaluating the anxiolytic and antidepressant potential of the plant in mice models. METHODS: The drie...

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Autores principales: Benneh, Charles Kwaku, Biney, Robert Peter, Adongo, Donatus Wewura, Mante, Priscilla Kolibea, Ampadu, Felix Agyei, Tandoh, Augustine, Jato, Jonathan, Woode, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151235/
https://www.ncbi.nlm.nih.gov/pubmed/30271633
http://dx.doi.org/10.1155/2018/1537371
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author Benneh, Charles Kwaku
Biney, Robert Peter
Adongo, Donatus Wewura
Mante, Priscilla Kolibea
Ampadu, Felix Agyei
Tandoh, Augustine
Jato, Jonathan
Woode, Eric
author_facet Benneh, Charles Kwaku
Biney, Robert Peter
Adongo, Donatus Wewura
Mante, Priscilla Kolibea
Ampadu, Felix Agyei
Tandoh, Augustine
Jato, Jonathan
Woode, Eric
author_sort Benneh, Charles Kwaku
collection PubMed
description INTRODUCTION: The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management of anxiety, psychosis, and epilepsy. AIM OF THE STUDY: We therefore aimed at evaluating the anxiolytic and antidepressant potential of the plant in mice models. METHODS: The dried stem bark was extracted with petroleum ether/ethyl acetate (50:50) mixture to obtain the extract, MAE. We employed Irwin's test to identify the preliminary behavioral and autonomic effects. Subsequently, MAE was administered per os to male mice and subsequently assessed, 1 h later, for anxiety parameters in the elevated plus maze (EPM) and the regular Suok tests. The forced swim (FST) and tail suspension (TST) tests were employed to assess the antidepressant potential of the extract (100-1000 mg kg(−1)). RESULTS: In our preliminary assay, MAE (100-5000 mg/kg) exhibited analgesic effects and a reduction in fear response in the Irwin's test. The spontaneous locomotor activity was reduced at 1000 mg/kg. Additionally, MAE (1000 mg/kg) increased the latency to PTZ-induced convulsions, and duration to sleep in the pentobarbitone induced sleeping time assay. MAE (1000 mg/kg), similar to diazepam, in the anxiolytic assay, increased the percentage time spent in the open arms while decreasing protected head dips and unprotected stretch attend postures in the EPM. Correspondingly, there was a reduction in anxiety-induced immobility and freezing in the Suok test (300 mg/kg) without loss of sensorimotor coordination. Additionally, there was a significant reduction in immobility duration in the FST (300 mg/kg) and TST (1000 mg/kg). CONCLUSION: The petroleum ether/ethyl acetate fractions of Maerua angolensis stem bark possess anxiolytic and acute antidepressant effects in mice.
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spelling pubmed-61512352018-09-30 Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice Benneh, Charles Kwaku Biney, Robert Peter Adongo, Donatus Wewura Mante, Priscilla Kolibea Ampadu, Felix Agyei Tandoh, Augustine Jato, Jonathan Woode, Eric Depress Res Treat Research Article INTRODUCTION: The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management of anxiety, psychosis, and epilepsy. AIM OF THE STUDY: We therefore aimed at evaluating the anxiolytic and antidepressant potential of the plant in mice models. METHODS: The dried stem bark was extracted with petroleum ether/ethyl acetate (50:50) mixture to obtain the extract, MAE. We employed Irwin's test to identify the preliminary behavioral and autonomic effects. Subsequently, MAE was administered per os to male mice and subsequently assessed, 1 h later, for anxiety parameters in the elevated plus maze (EPM) and the regular Suok tests. The forced swim (FST) and tail suspension (TST) tests were employed to assess the antidepressant potential of the extract (100-1000 mg kg(−1)). RESULTS: In our preliminary assay, MAE (100-5000 mg/kg) exhibited analgesic effects and a reduction in fear response in the Irwin's test. The spontaneous locomotor activity was reduced at 1000 mg/kg. Additionally, MAE (1000 mg/kg) increased the latency to PTZ-induced convulsions, and duration to sleep in the pentobarbitone induced sleeping time assay. MAE (1000 mg/kg), similar to diazepam, in the anxiolytic assay, increased the percentage time spent in the open arms while decreasing protected head dips and unprotected stretch attend postures in the EPM. Correspondingly, there was a reduction in anxiety-induced immobility and freezing in the Suok test (300 mg/kg) without loss of sensorimotor coordination. Additionally, there was a significant reduction in immobility duration in the FST (300 mg/kg) and TST (1000 mg/kg). CONCLUSION: The petroleum ether/ethyl acetate fractions of Maerua angolensis stem bark possess anxiolytic and acute antidepressant effects in mice. Hindawi 2018-09-09 /pmc/articles/PMC6151235/ /pubmed/30271633 http://dx.doi.org/10.1155/2018/1537371 Text en Copyright © 2018 Charles Kwaku Benneh et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Benneh, Charles Kwaku
Biney, Robert Peter
Adongo, Donatus Wewura
Mante, Priscilla Kolibea
Ampadu, Felix Agyei
Tandoh, Augustine
Jato, Jonathan
Woode, Eric
Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title_full Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title_fullStr Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title_full_unstemmed Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title_short Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
title_sort anxiolytic and antidepressant effects of maerua angolensis dc. stem bark extract in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151235/
https://www.ncbi.nlm.nih.gov/pubmed/30271633
http://dx.doi.org/10.1155/2018/1537371
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