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Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance
The typical helical flow within the human arterial system is widely used when designing cardiovascular devices, as this helical flow can be generated using the “crossed limbs” strategy of the bifurcated stent graft (BSG) and enhanced by the tapered structure of arteries. Here, we propose the use of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151236/ https://www.ncbi.nlm.nih.gov/pubmed/30271457 http://dx.doi.org/10.1155/2018/8054850 |
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author | Liu, Ming Wang, Zhenze Sun, Anqiang Deng, Xiaoyan |
author_facet | Liu, Ming Wang, Zhenze Sun, Anqiang Deng, Xiaoyan |
author_sort | Liu, Ming |
collection | PubMed |
description | The typical helical flow within the human arterial system is widely used when designing cardiovascular devices, as this helical flow can be generated using the “crossed limbs” strategy of the bifurcated stent graft (BSG) and enhanced by the tapered structure of arteries. Here, we propose the use of a deflected blended bifurcated stent graft (BBSG) with various tapers, using conventional blended BSGs with the same degree of taper as a comparison. Hemodynamic performances, including helical strength and wall shear stress- (WSS-) based indicators, were assessed. Displacement forces that may induce stent-graft migration were assessed using numerical simulations and in vitro experiments. The results showed that as the taper increased, the displacement force, helicity strength, and time-averaged wall shear stress (TAWSS) within the iliac grafts increased, whereas the oscillating shear index (OSI) and relative residence time (RRT) gradually decreased for both types of BBSGs. With identical tapers, deflected BBSGs, compared to conventional BBSGs, exhibited a wider helical structure and lower RRT on the iliac graft and lower displacement force; however, there were no differences in hemodynamic indicators. In summary, the presence of tapering facilitated helical flow and produced better hemodynamic performance but posed a higher risk of graft migration. Conventional and deflected BBSGs with taper might be the two optimal configurations for endovascular aneurysm repair, given the helical flow. The deflected BBSG provides a better configuration, compared to the conventional BBSG, when considering the reduction of migration risk. |
format | Online Article Text |
id | pubmed-6151236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61512362018-09-30 Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance Liu, Ming Wang, Zhenze Sun, Anqiang Deng, Xiaoyan Comput Math Methods Med Research Article The typical helical flow within the human arterial system is widely used when designing cardiovascular devices, as this helical flow can be generated using the “crossed limbs” strategy of the bifurcated stent graft (BSG) and enhanced by the tapered structure of arteries. Here, we propose the use of a deflected blended bifurcated stent graft (BBSG) with various tapers, using conventional blended BSGs with the same degree of taper as a comparison. Hemodynamic performances, including helical strength and wall shear stress- (WSS-) based indicators, were assessed. Displacement forces that may induce stent-graft migration were assessed using numerical simulations and in vitro experiments. The results showed that as the taper increased, the displacement force, helicity strength, and time-averaged wall shear stress (TAWSS) within the iliac grafts increased, whereas the oscillating shear index (OSI) and relative residence time (RRT) gradually decreased for both types of BBSGs. With identical tapers, deflected BBSGs, compared to conventional BBSGs, exhibited a wider helical structure and lower RRT on the iliac graft and lower displacement force; however, there were no differences in hemodynamic indicators. In summary, the presence of tapering facilitated helical flow and produced better hemodynamic performance but posed a higher risk of graft migration. Conventional and deflected BBSGs with taper might be the two optimal configurations for endovascular aneurysm repair, given the helical flow. The deflected BBSG provides a better configuration, compared to the conventional BBSG, when considering the reduction of migration risk. Hindawi 2018-09-09 /pmc/articles/PMC6151236/ /pubmed/30271457 http://dx.doi.org/10.1155/2018/8054850 Text en Copyright © 2018 Ming Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Ming Wang, Zhenze Sun, Anqiang Deng, Xiaoyan Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title | Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title_full | Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title_fullStr | Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title_full_unstemmed | Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title_short | Numerical and Experimental Investigation of Novel Blended Bifurcated Stent Grafts with Taper to Improve Hemodynamic Performance |
title_sort | numerical and experimental investigation of novel blended bifurcated stent grafts with taper to improve hemodynamic performance |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151236/ https://www.ncbi.nlm.nih.gov/pubmed/30271457 http://dx.doi.org/10.1155/2018/8054850 |
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