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The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients
This study aims to find the cut-off value and diagnostic accuracy of the use of RDW as initial investigation in enabling the differentiation between IDA and NTDT patients. Patients with microcytic anemia were enrolled in the training set and used to plot a receiving operating characteristics (ROC) c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151350/ https://www.ncbi.nlm.nih.gov/pubmed/30283620 http://dx.doi.org/10.4081/hr.2018.7605 |
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author | Piriyakhuntorn, Pokpong Tantiworawit, Adisak Rattanathammethee, Thanawat Chai-Adisaksopha, Chatree Rattarittamrong, Ekarat Norasetthada, Lalita |
author_facet | Piriyakhuntorn, Pokpong Tantiworawit, Adisak Rattanathammethee, Thanawat Chai-Adisaksopha, Chatree Rattarittamrong, Ekarat Norasetthada, Lalita |
author_sort | Piriyakhuntorn, Pokpong |
collection | PubMed |
description | This study aims to find the cut-off value and diagnostic accuracy of the use of RDW as initial investigation in enabling the differentiation between IDA and NTDT patients. Patients with microcytic anemia were enrolled in the training set and used to plot a receiving operating characteristics (ROC) curve to obtain the cut-off value of RDW. A second set of patients were included in the validation set and used to analyze the diagnostic accuracy. We recruited 94 IDA and 64 NTDT patients into the training set. The area under the curve of the ROC in the training set was 0.803. The best cut-off value of RDW in the diagnosis of NTDT was >21.0% with a sensitivity and specificity of 81.3% and 55.3% respectively. In the validation set, there were 34 IDA and 58 NTDT patients using the cut-off value of 21.0% to validate. The sensitivity, specificity, positive predictive value and negative predictive value were 84.5%, 70.6%, 83.1% and 72.7% respectively. We can therefore conclude that RDW >21.0% is useful in differentiating between IDA and NTDT patients with high diagnostic accuracy. |
format | Online Article Text |
id | pubmed-6151350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-61513502018-10-03 The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients Piriyakhuntorn, Pokpong Tantiworawit, Adisak Rattanathammethee, Thanawat Chai-Adisaksopha, Chatree Rattarittamrong, Ekarat Norasetthada, Lalita Hematol Rep Article This study aims to find the cut-off value and diagnostic accuracy of the use of RDW as initial investigation in enabling the differentiation between IDA and NTDT patients. Patients with microcytic anemia were enrolled in the training set and used to plot a receiving operating characteristics (ROC) curve to obtain the cut-off value of RDW. A second set of patients were included in the validation set and used to analyze the diagnostic accuracy. We recruited 94 IDA and 64 NTDT patients into the training set. The area under the curve of the ROC in the training set was 0.803. The best cut-off value of RDW in the diagnosis of NTDT was >21.0% with a sensitivity and specificity of 81.3% and 55.3% respectively. In the validation set, there were 34 IDA and 58 NTDT patients using the cut-off value of 21.0% to validate. The sensitivity, specificity, positive predictive value and negative predictive value were 84.5%, 70.6%, 83.1% and 72.7% respectively. We can therefore conclude that RDW >21.0% is useful in differentiating between IDA and NTDT patients with high diagnostic accuracy. PAGEPress Publications, Pavia, Italy 2018-09-05 /pmc/articles/PMC6151350/ /pubmed/30283620 http://dx.doi.org/10.4081/hr.2018.7605 Text en ©Copyright P. Piriyakhuntorn et al., 2018 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Piriyakhuntorn, Pokpong Tantiworawit, Adisak Rattanathammethee, Thanawat Chai-Adisaksopha, Chatree Rattarittamrong, Ekarat Norasetthada, Lalita The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title | The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title_full | The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title_fullStr | The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title_full_unstemmed | The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title_short | The role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
title_sort | role of red cell distribution width in the differential diagnosis of iron deficiency anemia and non-transfusiondependent thalassemia patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151350/ https://www.ncbi.nlm.nih.gov/pubmed/30283620 http://dx.doi.org/10.4081/hr.2018.7605 |
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