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The use of structural alerts to avoid the toxicity of pharmaceuticals

In order to identify compounds with potential toxicity problems, particular attention is paid to structural alerts, which are high chemical reactivity molecular fragments or fragments that can be transformed via bioactivation by human enzymes into fragments with high chemical reactivity. The concept...

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Detalles Bibliográficos
Autores principales:	Limban, Carmen, Nuţă, Diana C., Chiriţă, Cornel, Negreș, Simona, Arsene, Andreea L., Goumenou, Marina, Karakitsios, Spyros P., Tsatsakis, Aristidis M., Sarigiannis, Dimosthenis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151358/ https://www.ncbi.nlm.nih.gov/pubmed/30258789 http://dx.doi.org/10.1016/j.toxrep.2018.08.017

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