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Quantitative Structure–Activity Relationship Modeling of Kinase Selectivity Profiles

The discovery of selective inhibitors of biological target proteins is the primary goal of many drug discovery campaigns. However, this goal has proven elusive, especially for inhibitors targeting the well-conserved orthosteric adenosine triphosphate (ATP) binding pocket of kinase enzymes. The human...

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Detalles Bibliográficos
Autores principales:	Kothiwale, Sandeepkumar, Borza, Corina, Pozzi, Ambra, Meiler, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151389/ https://www.ncbi.nlm.nih.gov/pubmed/28925954 http://dx.doi.org/10.3390/molecules22091576

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