Cargando…

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs, we assessed the direct cyclooxygenase (COX) inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oniga, Smaranda Dafina, Pacureanu, Liliana, Stoica, Cristina Ioana, Palage, Mariana Doina, Crăciun, Alexandra, Rusu, Laurentiu Răzvan, Crisan, Elena-Luminita, Araniciu, Cătălin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151395/ https://www.ncbi.nlm.nih.gov/pubmed/28891941 http://dx.doi.org/10.3390/molecules22091507

Ejemplares similares

New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
por: Oniga, Smaranda Dafina, et al.
Publicado: (2017)

The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation
por: Araniciu, Cătălin, et al.
Publicado: (2014)

New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors
por: Marc, Gabriel, et al.
Publicado: (2018)

Inclusion of a Catechol-Derived Hydrazinyl-Thiazole (CHT) in β-Cyclodextrin Nanocavity and Its Effect on Antioxidant Activity: A Calorimetric, Spectroscopic and Molecular Docking Approach
por: Mic, Mihaela, et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents
por: Marc, Gabriel, et al.
Publicado: (2019)

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
por: Borcea, Anca-Maria, et al.
Publicado: (2021)

New Insights on the Activity and Selectivity of MAO-B Inhibitors through In Silico Methods
por: Pacureanu, Liliana, et al.
Publicado: (2023)

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation
por: Pele, Raluca, et al.
Publicado: (2022)

The Synthesis and Antiproliferative Activities of New Arylidene-Hydrazinyl-Thiazole Derivatives
por: Grozav, Adriana, et al.
Publicado: (2014)

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
por: Hawash, Mohammed, et al.
Publicado: (2023)

Thiazoles and Thiazolidinones as COX/LOX Inhibitors
por: Liaras, Konstantinos, et al.
Publicado: (2018)

Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular Docking Study, and Spectroscopic Investigation of their Binding Interaction with Bovine Serum Albumin
por: Pricopie, Andreea-Iulia, et al.
Publicado: (2019)

New Phenolic Derivatives of Thiazolidine-2,4-dione with Antioxidant and Antiradical Properties: Synthesis, Characterization, In Vitro Evaluation, and Quantum Studies
por: Marc, Gabriel, et al.
Publicado: (2019)

Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines
por: STOICA, CRISTINA IOANA, et al.
Publicado: (2015)

Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents
por: El-Damasy, Ashraf K., et al.
Publicado: (2023)

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation
por: Marc, Gabriel, et al.
Publicado: (2023)

New Thiazole Carboxamide Derivatives as COX Inhibitors: Design, Synthesis, Anticancer Screening, In Silico Molecular Docking, and ADME Profile Studies
por: Hawash, Mohammed, et al.
Publicado: (2023)

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation
por: Nastasă, Cristina, et al.
Publicado: (2015)

Design, synthesis, docking study and anticancer evaluation of new trimethoxyphenyl pyridine derivatives as tubulin inhibitors and apoptosis inducers
por: Hagras, Mohamed, et al.
Publicado: (2021)

Antioxidant Activity Evaluation and Assessment of the Binding Affinity to HSA of a New Catechol Hydrazinyl-Thiazole Derivative
por: Mic, Mihaela, et al.
Publicado: (2022)

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study
por: Gomha, Sobhi M, et al.
Publicado: (2021)

Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Candida Activity Evaluation and Interaction with Bovine Serum Albumine
por: Pricopie, Andreea-Iulia, et al.
Publicado: (2020)

Homology Modeling and Molecular Docking Approaches for the Proposal of Novel Insecticides against the African Malaria Mosquito (Anopheles gambiae)
por: Crisan, Luminita, et al.
Publicado: (2022)

Molecular docking analysis of curcumin analogues with COX-2
por: Sohilait, Mario Rowan, et al.
Publicado: (2017)

Molecular docking analysis of COX-2 for potential inhibitors
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
por: El-Abd, Azhar O., et al.
Publicado: (2022)

Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
por: Kartsev, Victor, et al.
Publicado: (2022)

Using DUCK-Net for polyp image segmentation
por: Dumitru, Razvan-Gabriel, et al.
Publicado: (2023)

Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening
por: Marc, Gabriel, et al.
Publicado: (2021)

Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
por: Cahill, Michael M., et al.
Publicado: (2017)

Molecular docking analysis of doronine derivatives with human COX-2
por: Hussain, Sardar, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors
por: Shahrasbi, Mahsa, et al.
Publicado: (2018)

Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents
por: Shawky, Ahmed M., et al.
Publicado: (2021)

Trial Protocol for Evaluating Platforms for Growing Microgreens in Hydroponic Conditions
por: Moraru, Paula Ioana, et al.
Publicado: (2022)

Rapid thermal annealing for high-quality ITO thin films deposited by radio-frequency magnetron sputtering
por: Prepelita, Petronela, et al.
Publicado: (2019)

A new spike train metric
por: Rusu, Cătălin V, et al.
Publicado: (2010)

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors
por: Xie, Zhenzhen, et al.
Publicado: (2017)

Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug
por: Gomha, Sobhi M., et al.
Publicado: (2015)

New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking
por: Althagafi, Ismail, et al.
Publicado: (2019)

Meso-Substituted Thiazole Orange for Selective Fluorescence Detection to G-Quadruplex DNA and Molecular Docking Simulation
por: Guan, Li, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dkasvov0asr05ghoum3otunjmc